Document Detail


Salience signals in the right temporoparietal junction facilitate value-based decisions.
MedLine Citation:
PMID:  23325225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Value-based decisions optimize the relation of costs and benefits. Costs and benefits confer not only value but also salience, which may influence decision making through attentional mechanisms. However, the computational and neurobiological role of salience in value-based decisions remains elusive. Here we develop and contrast two formal concepts of salience for value-based choices involving costs and benefits. Specifically, global salience (GS) first integrates costs and benefits and then determines salience based on this overall sum, whereas elemental salience (ES) first determines the salience of costs and benefits before integrating them. We dissociate the behavioral and neural effects of GS and ES from those of value using a value-based decision-making task and fMRI in humans. Specifically, we show that value guides choices and correlates with neural signals in the striatum. In contrast, only ES but not GS impacts decision making by speeding up reaction times. Moreover, activity in the right temporoparietal junction (RTPJ) reflects only ES and correlates with its response-accelerating behavioral effects. Finally, we report an ES-dependent change in functional connectivity between the RTPJ and the locus ceruleus, suggesting noradrenergic processes underlying the response-facilitating effects of ES on decision making. Together, these results support a novel concept of salience in value-based decision making and suggest a computational, anatomical, and neurochemical dissociation of value- and salience-based factors supporting value-based choices.
Authors:
Thorsten Kahnt; Philippe N Tobler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-04-01     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  863-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Association Learning / physiology
Brain Mapping
Corpus Striatum / physiology
Cues
Decision Making / physiology*
Female
Functional Neuroimaging
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Parietal Lobe / physiology*
Photic Stimulation
Reaction Time / physiology
Reward
Temporal Lobe / physiology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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