Document Detail


Salicylic acid derivatives: synthesis, features and usage as therapeutic tools.
MedLine Citation:
PMID:  22098318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: In the field of medicinal chemistry, there is a growing interest in the use of small molecules. Although acetyl salicylic acid is well known for medical applications, little is known about other salicylic acid derivatives, and there is serious lack of data and information on the effects and biological evaluation that connect them.
AREAS COVERED: This review covers the synthesis and drug potencies of salicylic acid derivatives. After a brief overview of the information on salicylic acid and its features, a detailed review of salicylic acids as drugs and prodrugs, usage as cyclooxygenase inhibitors, properties in plants, synthesis and recent patents, is developed.
EXPERT OPINION: Salicylic acid research is still an important area and innovations continue to arise, which offer hope for new therapeutics in related fields. It is anticipated that this review will guide the direction of long-term drug/nutraceutical safety trials and stimulate ideas for future research.
Authors:
Deniz Ekinci; Murat Sentürk; Ömer İrfan Küfrevioğlu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on therapeutic patents     Volume:  21     ISSN:  1744-7674     ISO Abbreviation:  Expert Opin Ther Pat     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-21     Completed Date:  2012-03-26     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9516419     Medline TA:  Expert Opin Ther Pat     Country:  England    
Other Details:
Languages:  eng     Pagination:  1831-41     Citation Subset:  IM    
Affiliation:
Ondokuz Mayıs University, Agricultural Faculty, Department of Agricultural Biotechnology, Samsun, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Cyclooxygenase Inhibitors* / chemical synthesis,  pharmacology,  therapeutic use
Drug Design*
Humans
Male
Patents as Topic
Plants / drug effects
Prodrugs* / chemical synthesis,  pharmacology,  therapeutic use
Salicylates* / chemical synthesis,  pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Prodrugs; 0/Salicylates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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