Document Detail

Salicylate treatment of epidemic Kawasaki disease in New York City.
MedLine Citation:
PMID:  553328     Owner:  NLM     Status:  MEDLINE    
Kawasaki disease, mucocutaneous lymph node syndrome, thought to be rare in the continental United States, occurred in epidemic form in New York City and adjacent New York and New Jersey in November-December, 1977. Aspirin and corticosteroids, reported to be ineffective treatment, were found to completely control the illness in affected children, provided adequate doses to achieve therapeutic blood levels were administered. Patients were found to malabsorb aspirin (and perhaps also to destroy it) and so required extraordinarily high doses during the acute phase; during recovery, doses had to be lowered to the usual range to avoid toxicity. The need for hospitalization and morbidity were reduced and, hopefully, mortality will also be reduced. The importance of not judging a drug ineffective in a disease without demonstrating adequate serum levels was again shown.
J C Jacobs
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  1     ISSN:  0163-4356     ISO Abbreviation:  Ther Drug Monit     Publication Date:  1979  
Date Detail:
Created Date:  1981-02-24     Completed Date:  1981-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  123-30     Citation Subset:  IM    
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MeSH Terms
Aspirin / therapeutic use*
Child, Preschool
Disease Outbreaks
Feces / analysis
Lymphatic Diseases / drug therapy*
Mucocutaneous Lymph Node Syndrome / drug therapy*,  epidemiology
New York City
Salicylates / blood,  urine
Reg. No./Substance:
0/Salicylates; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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