Document Detail


Salicylate-induced enzymuria: comparison with other anti-inflammatory agents.
MedLine Citation:
PMID:  311157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-acetyl-beta glucosaminidase (NAG) enzymuria was used as a marker of renal injury in patients with rheumatic disease. An elevated NAG level was particularly common in patients receiving gold or aspirin therapy. The multiplicity of drugs received and the unknown role of underlying disease in these patients led to a study in healthy volunteers. Customary therapeutic doses of aspirin, choline salicylate, ibuprofen, indomethacin and acetaminophen did not produce enzymuria. Large single doses of salicylates equivalent to 6 tablets of aspirin consistently did produce enzymuria. The size of the individual dose in relation to body weight was more important than the total daily dose. NAG enzymuria appears to be a sensitive tool for identifying potentially nephrotoxic drugs.
Authors:
R A Proctor; C M Kunin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  65     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  987-93     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / adverse effects
Acetylglucosaminidase / urine*
Adult
Anti-Inflammatory Agents / adverse effects*
Aspirin / administration & dosage,  adverse effects
Gold / administration & dosage,  adverse effects
Hexosaminidases / urine*
Humans
Ibuprofen / adverse effects
Indomethacin / adverse effects
Kidney / drug effects*
Kidney Diseases / chemically induced,  diagnosis,  enzymology
Lysosomes / enzymology
Rheumatic Diseases / drug therapy
Salicylates / administration & dosage,  adverse effects*,  therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Salicylates; 103-90-2/Acetaminophen; 15687-27-1/Ibuprofen; 50-78-2/Aspirin; 53-86-1/Indomethacin; 7440-57-5/Gold; EC 3.2.1.-/Hexosaminidases; EC 3.2.1.52/Acetylglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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