Document Detail

Salicylate-induced translocation of prestin having mutation in the GTSRH sequence to the plasma membrane.
MedLine Citation:
PMID:  20388516     Owner:  NLM     Status:  MEDLINE    
Prestin is a key molecule for mammalian hearing. The present study investigated changes in characteristics of prestin by culturing prestin-transfected cells with salicylate, an antagonist of prestin. As a result, the plasma membrane localization of prestin bearing a mutation in the GTSRH sequence, which normally accumulates in the cytoplasm, was recovered. Moreover, the nonlinear capacitance of the majority of the mutants, which is a signature of prestin activity, was also recovered. Thus, the present study discovered a new effect of salicylate on prestin, namely, the promotion of the plasma membrane expression of prestin mutants in an active state.
Shun Kumano; Koji Iida; Kenji Ishihara; Michio Murakoshi; Kouhei Tsumoto; Katsuhisa Ikeda; Izumi Kumagai; Toshimitsu Kobayashi; Hiroshi Wada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-11
Journal Detail:
Title:  FEBS letters     Volume:  584     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2327-32     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Department of Bioengineering and Robotics, Tohoku University, Sendai, Japan.
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MeSH Terms
Base Sequence
Biochemical Processes
Cell Membrane / genetics*,  metabolism*
Cell Movement / genetics
Electric Capacitance*
Hearing / genetics
Ion Transport / genetics
Mammals / genetics,  metabolism
Protein Transport / genetics
Salicylic Acid / metabolism*
Reg. No./Substance:
69-72-7/Salicylic Acid

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