| Salicylate-induced translocation of prestin having mutation in the GTSRH sequence to the plasma membrane. | |
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MedLine Citation:
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PMID: 20388516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prestin is a key molecule for mammalian hearing. The present study investigated changes in characteristics of prestin by culturing prestin-transfected cells with salicylate, an antagonist of prestin. As a result, the plasma membrane localization of prestin bearing a mutation in the GTSRH sequence, which normally accumulates in the cytoplasm, was recovered. Moreover, the nonlinear capacitance of the majority of the mutants, which is a signature of prestin activity, was also recovered. Thus, the present study discovered a new effect of salicylate on prestin, namely, the promotion of the plasma membrane expression of prestin mutants in an active state. |
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Authors:
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Shun Kumano; Koji Iida; Kenji Ishihara; Michio Murakoshi; Kouhei Tsumoto; Katsuhisa Ikeda; Izumi Kumagai; Toshimitsu Kobayashi; Hiroshi Wada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-11 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2327-32 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Bioengineering and Robotics, Tohoku University, Sendai, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Biochemical Processes Cell Membrane / genetics*, metabolism* Cell Movement / genetics Electric Capacitance* Hearing / genetics Ion Transport / genetics Mammals / genetics, metabolism Mutation* Protein Transport / genetics Salicylic Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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69-72-7/Salicylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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