Document Detail

Salicylate and gastric mucosal damage.
MedLine Citation:
PMID:  31594     Owner:  NLM     Status:  MEDLINE    
The mechanism(s) of salicylate-induced damage of the gastric mucosa is complex. The presence of acid in the lumen is essential for the occurrence of such injury. Although the absorption of salicylate is greater in the presence of acid, salicylate can selectively increase cation permeability both in the absence and presence of acid. Recent studies suggest that this permits increased diffusion of luminal acid into the tissue, which leads to major permeability changes of the mucosa. Salicylate also affects metabolic processes of the gastric mucosa, which appear to be independent of the increased diffusion of acid into the tissue also caused by salicylate. The release of histamine, which has been shown to occur in vivo as a result of mucosal damage, does not appear to intensify existing mucosal injury in an isolated system.
D Fromm
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pediatrics     Volume:  62     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-02-26     Completed Date:  1979-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  938-42     Citation Subset:  AIM; IM    
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MeSH Terms
Biological Transport, Active / drug effects
Chlorides / metabolism
Gastric Juice / secretion
Gastric Mucosa / drug effects*
Gastrointestinal Hemorrhage / chemically induced
Hydrogen-Ion Concentration
Salicylates / adverse effects*
Sodium / metabolism
Reg. No./Substance:
0/Chlorides; 0/Salicylates; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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