| Salicylate and gastric mucosal damage. | |
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MedLine Citation:
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PMID: 31594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanism(s) of salicylate-induced damage of the gastric mucosa is complex. The presence of acid in the lumen is essential for the occurrence of such injury. Although the absorption of salicylate is greater in the presence of acid, salicylate can selectively increase cation permeability both in the absence and presence of acid. Recent studies suggest that this permits increased diffusion of luminal acid into the tissue, which leads to major permeability changes of the mucosa. Salicylate also affects metabolic processes of the gastric mucosa, which appear to be independent of the increased diffusion of acid into the tissue also caused by salicylate. The release of histamine, which has been shown to occur in vivo as a result of mucosal damage, does not appear to intensify existing mucosal injury in an isolated system. |
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Authors:
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D Fromm |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Pediatrics Volume: 62 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1979-02-26 Completed Date: 1979-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 938-42 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport, Active / drug effects Chlorides / metabolism Diffusion Gastric Juice / secretion Gastric Mucosa / drug effects* Gastrointestinal Hemorrhage / chemically induced Humans Hydrogen-Ion Concentration Permeability Salicylates / adverse effects* Sodium / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 0/Salicylates; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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