Document Detail

Salicylamide inhibitors of influenza virus fusion.
MedLine Citation:
PMID:  10937716     Owner:  NLM     Status:  MEDLINE    
Structural variation of the quinolizidine heterocycle of the influenza fusion inhibitor BMY-27709 was examined by several topological dissections in order to illuminate the critical features of the ring system. This exercise resulted in the identification of a series of synthetically more accessible decahydroquinolines that retained the structural elements of BMY-27709 important for antiviral activity. The 2-methyl-cis-decahydroquinoline 6f was the most potent influenza inhibitor identified that demonstrated an EC50 of 90 ng/mL in a plaque reduction assay.
K D Combrink; H B Gulgeze; K L Yu; B C Pearce; A K Trehan; J Wei; M Deshpande; M Krystal; A Torri; G Luo; C Cianci; S Danetz; L Tiley; N A Meanwell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  10     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-06     Completed Date:  2000-12-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1649-52     Citation Subset:  IM    
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 05492, USA.
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MeSH Terms
Antiviral Agents / chemistry,  pharmacology*
Cell Line
Membrane Fusion / drug effects*
Orthomyxoviridae / drug effects*,  physiology
Quinolizines / chemistry,  pharmacology*
Salicylamides / chemistry,  pharmacology*
Reg. No./Substance:
0/Antiviral Agents; 0/BMY 27709; 0/Quinolizines; 0/Salicylamides; 65-45-2/salicylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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