Document Detail


Salicylamide inhibitors of influenza virus fusion.
MedLine Citation:
PMID:  10937716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Structural variation of the quinolizidine heterocycle of the influenza fusion inhibitor BMY-27709 was examined by several topological dissections in order to illuminate the critical features of the ring system. This exercise resulted in the identification of a series of synthetically more accessible decahydroquinolines that retained the structural elements of BMY-27709 important for antiviral activity. The 2-methyl-cis-decahydroquinoline 6f was the most potent influenza inhibitor identified that demonstrated an EC50 of 90 ng/mL in a plaque reduction assay.
Authors:
K D Combrink; H B Gulgeze; K L Yu; B C Pearce; A K Trehan; J Wei; M Deshpande; M Krystal; A Torri; G Luo; C Cianci; S Danetz; L Tiley; N A Meanwell
Related Documents :
820256 - Bacteriological quality assessment of fresh marketed lettuce and fennel.
12225196 - Nuclear fusion in collapsing bubbles-is it there? an attempt to repeat the observation ...
16042256 - Potential of a tropical subsurface constructed wetland to remove phenol from pre-treate...
8877666 - 2 multi-center trials assessing the clinical efficacy of 5% sanguinarine in a biodegrad...
21327796 - Effects of β2-adrenergic stimulation on exercise capacity in normal subjects.
17041016 - Self-perceived weight status and exercise adequacy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  10     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-06     Completed Date:  2000-12-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1649-52     Citation Subset:  IM    
Affiliation:
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 05492, USA. keith.combrink@bms.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / chemistry,  pharmacology*
Cell Line
Dogs
Membrane Fusion / drug effects*
Orthomyxoviridae / drug effects*,  physiology
Quinolizines / chemistry,  pharmacology*
Salicylamides / chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/BMY 27709; 0/Quinolizines; 0/Salicylamides; 65-45-2/salicylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship stu...
Next Document:  Phenyl sulfur mustard derivatives of distamycin A.