Document Detail


Salbutamol in cardiogenic shock complicating acute myocardial infarction.
MedLine Citation:
PMID:  7378211     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravenous salbutamol (13 microgram/min) has been given to 31 patients with cardiogenic shock complicating acute myocardial infarction. Haemodynamic measurements were made in nine of these patients. Salbutamol increased cardiac index by 41 per cent from 1.25 +/- 0.06 l/min per m2 to 1.76 +/- 0.19 l/min per m2 and decreased systemic vascular resistance by 16 per cent from 26.2 +/- 1.9 units to 21.9 +/- 2.1 units. Heart rate rose by 13 per cent from 95 +/- 4.5 beats/min to 106 +/- 6.0 beats/min. Pulmonary artery end-diastolic pressure fell from 20.6 +/- 1.7 mmHg to 16.9+/- 1.9 mmHg. Of the 31 patients, eight survived to leave hospital (27%). Five of the survivors had initial low heart rates and in these patients the clinical improvement was probably attributable to the positive chronotropic action of salbutamol. In the remaining three survivors clinical improvement was probably a result of salbutamol mediated afterload reduction. Salbutamol may be useful in the treatment of cardiogenic shock and pump failure complicating acute myocardial infarction.
Authors:
J R Dawson; P A Poole-Wilson; G C Sutton
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  43     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  523-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Albuterol / pharmacology,  therapeutic use*
Female
Hemodynamics / drug effects
Humans
Male
Middle Aged
Myocardial Infarction / complications*
Shock, Cardiogenic / drug therapy*,  etiology
Chemical
Reg. No./Substance:
18559-94-9/Albuterol
Comments/Corrections

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