Document Detail

Salbutamol and high-intensity treadmill running in nonasthmatic highly conditioned athletes.
MedLine Citation:
PMID:  7552768     Owner:  NLM     Status:  MEDLINE    
Salbutamol is a widely used drug among elite athletes. We wanted to provide more information on the effects of salbutamol in nonasthmatic athletes. Seventeen highly conditioned male athletes (VO2max > 70 participated in a randomized, double-blind and placebo-controlled cross-over study. Nebulized salbutamol (0.05 mg/kg) or placebo was inhaled prior to a high intensity (110% of VO2max) treadmill run to exhaustion. The measured variables included endurance time, oxygen uptake, ventilation, breathing rate, heart rate, and oxygen saturation. Lung function was measured as forced expiratory volume in the first second (FEV1) before and after medication, and during the recovery from the run. The high intensity runs led to total exhaustion after 4-10 min. A close-to-significant shortening in endurance time was found when salbutamol was given. During the running (0-4 min) the oxygen uptake was slightly lower and the heart rate was slightly higher when salbutamol was given. No differences were found in peak oxygen uptake, peak heart rate, ventilation, breathing rate or oxygen saturation. FEV1 reflected an increase in airway caliber after the inhalation of salbutamol. These changes were still present in the recovery from the test run with the exception of the measurement immediately after the exercise. Although evidence for beta-adrenergic stimulation was found, it was concluded that a therapeutic dose of nebulized salbutamol does not improve performance in highly trained athletes during a high-intensity run to exhaustion.
T Heir; H Stemshaug
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  5     ISSN:  0905-7188     ISO Abbreviation:  Scand J Med Sci Sports     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-11-13     Completed Date:  1995-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  IM    
Norwegian University of Sport and Physical Education, Oslo.
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MeSH Terms
Administration, Inhalation
Adrenergic beta-Agonists / administration & dosage,  pharmacology*
Albuterol / administration & dosage,  pharmacology*
Bronchi / drug effects,  pathology
Bronchodilator Agents / administration & dosage,  pharmacology*
Cross-Over Studies
Double-Blind Method
Exercise Test
Exercise Tolerance
Forced Expiratory Volume / drug effects
Heart Rate / drug effects
Lung / drug effects*
Nebulizers and Vaporizers
Oxygen / blood
Oxygen Consumption / drug effects
Physical Endurance
Respiration / drug effects
Running / physiology*
Time Factors
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Bronchodilator Agents; 0/Placebos; 18559-94-9/Albuterol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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