Document Detail

Salbutamol and cardiac arrhythmias.
MedLine Citation:
PMID:  7238086     Owner:  NLM     Status:  MEDLINE    
A study was carried out in 7 patients with chronic obstructive airways disease to investigate the possibility of serious cardiovascular effects after the intravenous infusion of salbutamol. Patients received salbutamol starting at 5 micrograms/min and increasing gradually to 20 micrograms/min. There results of blood gas analysis showed that all but one of the patients were hypoxic and there was evidence of improved ventilation at the end of the first hour of infusion in most, with a mean reduction of 0.43 kPa in PaCO2. The patients' ECGs were monitored continuously before and during the infusion. There was an increase in mean heart rate, but not significant arrhythmias clearly provoked by salbutamol were seen. It is concluded that these findings indicate that any cardiovascular risks with parenteral salbutamol are negligible.
S M Crawford; D W Miles
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Current medical research and opinion     Volume:  7     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  1981  
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  410-5     Citation Subset:  IM    
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MeSH Terms
Albuterol / administration & dosage,  adverse effects*
Arrhythmias, Cardiac / chemically induced*
Heart Rate
Infusions, Parenteral
Lung Diseases, Obstructive / drug therapy*
Middle Aged
Reg. No./Substance:

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