| Is Salamol less effective than Ventolin? A randomised, blinded, crossover study in New Zealand. | |
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MedLine Citation:
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PMID: 18157200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The effectiveness of the fully subsidised bronchodilator in New Zealand, Salamol, has recently been questioned. We compared the efficacy of Salamol and Ventolin inhalers in relieving acute bronchospasm. We also tested the efficacy of partially used Salamol inhalers because of concerns that the device may become blocked during use. METHODS: 12 asthmatic subjects were enrolled in this randomised, single-blind, 3-way crossover study. Subjects inhaled methacholine to produce a 20% fall in forced expiratory volume at 1 second (FEV1) on 3 different days. Salbutamol was given post-bronchoconstriction as Ventolin, Salamol (new), or Salamol (used) in random order. Inhalations of 100, 100, and 200 mcg salbutamol were delivered at 5 minute intervals via spacer and FEV1 was measured 5 minutes after each dose. The main outcome variable was the area under the salbutamol dose response curve. RESULTS: There was no significant difference in the bronchodilator response to salbutamol whether delivered as Ventolin or Salamol (p=0.63). Furthermore, there was no difference in bronchodilator response between used Salamol inhalers and new Salamol inhalers (p=0.60) or between used Salamol inhalers and Ventolin (p=0.08). The final FEV1s at 15 minutes (after a total of 400mcg salbutamol) were also similar for the different inhalers. CONCLUSIONS: We found no evidence that either new or partially used Salamol inhalers are less effective at relieving acute bronchoconstriction than Ventolin. |
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Authors:
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Catherina L Chang; Manisha Cooray; Graham Mills; Robert J Hancox |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-12-14 |
Journal Detail:
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Title: The New Zealand medical journal Volume: 120 ISSN: 1175-8716 ISO Abbreviation: N. Z. Med. J. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-24 Completed Date: 2008-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401067 Medline TA: N Z Med J Country: New Zealand |
Other Details:
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Languages: eng Pagination: U2874 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand. changc@waikatodhb.govt.nz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adrenergic beta-Agonists / administration & dosage, therapeutic use* Adult Albuterol / administration & dosage, therapeutic use* Asthma / drug therapy*, physiopathology Cross-Over Studies Drugs, Generic / administration & dosage, therapeutic use* Female Follow-Up Studies Forced Expiratory Volume / drug effects Humans Male Middle Aged New Zealand Patient Compliance Single-Blind Method Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Drugs, Generic; 18559-94-9/Albuterol |
| Comments/Corrections | |
Comment In:
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N Z Med J. 2007;120(1267):U2875
[PMID:
18157201
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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