| Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells. | |
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MedLine Citation:
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PMID: 21173435 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Phytochemicals have been used as potential chemopreventive or chemotherapeutic agents. However, there are data suggesting a mutagenic effect of some phytochemicals. We hypothesized that safrole would have anticancer effects on human oral squamous cell carcinoma HSC-3 cells. Safrole decreased the percentage of viable HSC-3 cells via induction of apoptosis by an increased level of cytosolic Ca(2+) and a reduction in the mitochondrial membrane potential (ΔΨ(m)). Changes in the membrane potential were associated with changes in the Bax, release of cytochrome c from mitochondria, and activation of downstream caspases-9 and -3, resulting in apoptotic cell death. In vivo studies also showed that safrole reduced the size and volume of an HSC-3 solid tumor on a xenograft athymic nu/nu mouse model. Western blotting and flow cytometric analysis studies confirmed that safrole-mediated apoptotic cell death of HSC-3 cells is regulated by cytosolic Ca(2+) and by mitochondria- and Fas-dependent pathways. |
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Authors:
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F-S Yu; J-S Yang; C-S Yu; C-C Lu; J-H Chiang; C-W Lin; J-G Chung |
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Publication Detail:
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Type: Journal Article Date: 2010-12-20 |
Journal Detail:
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Title: Journal of dental research Volume: 90 ISSN: 1544-0591 ISO Abbreviation: J. Dent. Res. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 168-74 Citation Subset: D; IM |
Affiliation:
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Department of Dental Hygiene. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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