Document Detail


Safety of varicella vaccine after licensure in the United States: experience from reports to the vaccine adverse event reporting system, 1995-2005.
MedLine Citation:
PMID:  18419393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Widespread use of varicella vaccine in the United States could enable detection of rare adverse events not identified previously. We reviewed data from 1995 to 2005 from the Vaccine Adverse Event Reporting System, including data from laboratory analyses, to distinguish adverse events associated with wild-type varicella-zoster virus (VZV) versus those associated with vaccine strain. Almost 48 million doses of varicella vaccine were distributed between 1995 and 2005. There were 25,306 adverse events reported (52.7/100,000 doses distributed); 5.0% were classified as serious (2.6/100,000 doses distributed). Adverse events associated with evidence of vaccine-strain VZV included meningitis in patients with concurrent herpes zoster. Patients with genetic predispositions may rarely have disease triggered by receipt of varicella vaccine. Overall, serious adverse events reported after varicella vaccination continue to be rare and must be considered relative to the substantial benefits of varicella vaccination. Ongoing safety surveillance and further studies may shed light on some of the hypothesized associations.
Authors:
Sandra S Chaves; Penina Haber; Kimp Walton; Robert P Wise; Hector S Izurieta; D Scott Schmid; Jane F Seward
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  197 Suppl 2     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-05-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S170-7     Citation Subset:  AIM; IM    
Affiliation:
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. schaves@cdc.gov
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adverse Drug Reaction Reporting Systems* / statistics & numerical data
Centers for Disease Control and Prevention (U.S.)
Chickenpox / epidemiology,  mortality,  prevention & control
Chickenpox Vaccine / administration & dosage,  adverse effects*
Child
Child, Preschool
Herpes Zoster / epidemiology,  virology
Herpesvirus 3, Human / isolation & purification
Humans
Infant
Licensure
Meningitis, Viral / epidemiology,  virology
United States / epidemiology
Chemical
Reg. No./Substance:
0/Chickenpox Vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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