Document Detail


Safety and usefulness of intravenous iron sucrose in the management of preoperative anemia in patients with menorrhagia: a phase IV, open-label, prospective, randomized study.
MedLine Citation:
PMID:  19332985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to compare the efficacy, safety and achievement of the target hemoglobin level (Hb >or=10 g/dl) in patients with preoperative anemia due to menorrhagia who received intravenous iron sucrose compared with oral iron protein succinylate for anemia management. METHODS: Seventy-six patients with Hb levels <9.0 g/dl who were scheduled to undergo surgical treatment were randomized to receive either intravenous iron sucrose (based on the calculated total iron deficit divided into 2 ampoule infusions intravenously 3 times a week, beginning 3 weeks before surgery) or oral iron (80 mg/day of oral iron protein succinylate daily). RESULTS: The intravenous iron group had higher increases in Hb (3.0 vs. 0.8 g/dl; p < 0.0001) and ferritin levels (170.1 vs. 4.1 microg/l; p < 0.0001) than the oral iron group. Achieving the target Hb was also higher in the intravenous iron group than in the oral iron group (76.7 vs. 11.5%; p < 0.0001). There were tolerable adverse events in both groups. CONCLUSION: Preoperative intravenous iron sucrose administration is more effective than oral iron and is as safe as oral iron therapy in the correction of preoperative anemia due to menorrhagia.
Authors:
Yun Hwan Kim; Hyun Hoon Chung; Soon-Beom Kang; Seung Cheol Kim; Young Tae Kim
Related Documents :
18299495 - Association of activated vitamin d treatment and mortality in chronic kidney disease.
12691505 - Improvement in clinical outcome by early nephrology referral in type ii diabetics on ma...
18777125 - Reduction in incidence of lymphocele following extraperitoneal radical prostatectomy an...
10603115 - Neurodevelopmental outcome of children initiating peritoneal dialysis in early infancy.
12587075 - Experimental herpes simplex virus encephalitis: a combination therapy of acyclovir and ...
21691805 - Mild hypoglycaemic attacks induced by sulphonylureas related to cyp2c9, cyp2c19 and cyp...
Publication Detail:
Type:  Clinical Trial, Phase IV; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2009-03-31
Journal Detail:
Title:  Acta haematologica     Volume:  121     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  IM    
Copyright Information:
(c) 2009 S. Karger AG, Basel.
Affiliation:
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Anemia / blood,  therapy*
Female
Ferric Compounds / administration & dosage*
Ferritins / blood
Hematinics / administration & dosage*
Hemoglobins / analysis
Humans
Infusions, Intravenous
Menorrhagia / blood,  therapy*
Middle Aged
Preoperative Care*
Prospective Studies
Chemical
Reg. No./Substance:
0/Ferric Compounds; 0/Hematinics; 0/Hemoglobins; 8047-67-4/ferric oxide, saccharated; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Economic impact of hyponatremia in hospitalized patients: a retrospective cohort study.
Next Document:  Hemospermia in patients with congenital coagulation disorders: a study of three cases.