Document Detail

Safety and usefulness of intravenous iron sucrose in the management of preoperative anemia in patients with menorrhagia: a phase IV, open-label, prospective, randomized study.
MedLine Citation:
PMID:  19332985     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to compare the efficacy, safety and achievement of the target hemoglobin level (Hb >or=10 g/dl) in patients with preoperative anemia due to menorrhagia who received intravenous iron sucrose compared with oral iron protein succinylate for anemia management. METHODS: Seventy-six patients with Hb levels <9.0 g/dl who were scheduled to undergo surgical treatment were randomized to receive either intravenous iron sucrose (based on the calculated total iron deficit divided into 2 ampoule infusions intravenously 3 times a week, beginning 3 weeks before surgery) or oral iron (80 mg/day of oral iron protein succinylate daily). RESULTS: The intravenous iron group had higher increases in Hb (3.0 vs. 0.8 g/dl; p < 0.0001) and ferritin levels (170.1 vs. 4.1 microg/l; p < 0.0001) than the oral iron group. Achieving the target Hb was also higher in the intravenous iron group than in the oral iron group (76.7 vs. 11.5%; p < 0.0001). There were tolerable adverse events in both groups. CONCLUSION: Preoperative intravenous iron sucrose administration is more effective than oral iron and is as safe as oral iron therapy in the correction of preoperative anemia due to menorrhagia.
Yun Hwan Kim; Hyun Hoon Chung; Soon-Beom Kang; Seung Cheol Kim; Young Tae Kim
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Publication Detail:
Type:  Clinical Trial, Phase IV; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2009-03-31
Journal Detail:
Title:  Acta haematologica     Volume:  121     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  IM    
Copyright Information:
(c) 2009 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
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MeSH Terms
Administration, Oral
Anemia / blood,  therapy*
Ferric Compounds / administration & dosage*
Ferritins / blood
Hematinics / administration & dosage*
Hemoglobins / analysis
Infusions, Intravenous
Menorrhagia / blood,  therapy*
Middle Aged
Preoperative Care*
Prospective Studies
Reg. No./Substance:
0/Ferric Compounds; 0/Hematinics; 0/Hemoglobins; 8047-67-4/ferric oxide, saccharated; 9007-73-2/Ferritins

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