Document Detail

Safety and tolerability of cladribine tablets in multiple sclerosis: the CLARITY (CLAdRIbine Tablets treating multiple sclerosis orallY) study.
MedLine Citation:
PMID:  21228029     Owner:  NLM     Status:  Publisher    
Background: Cladribine is a synthetic deoxyadenosine analogue in development as an oral multiple sclerosis (MS) therapy. Objective: To report in detail the safety findings from the 96-week, phase III, double-blind CLARITY study, which evaluated treatment with cladribine tablets in relapsing-remitting MS. Methods: A total of 1,326 patients were randomized 1 : 1 : 1 to two short-course regimens of cladribine tablets (3.5 or 5.25 mg/kg cumulative dose over 96 weeks) or placebo. Safety assessments included monitoring for adverse events (AEs), routine physical and neurologic examinations and frequent laboratory parameter assessments. Results: Of the randomized patients, 88.6% completed treatment with cladribine tablets versus 86.3% with placebo. Lymphopenia was the most commonly reported AE in patients treated with cladribine tablets and was anticipated based on the mechanism of action. The incidence of infections was 48.3% with cladribine tablets and 42.5% with placebo, with 99.1% and 99.0% rated mild-to-moderate by investigators. Herpes zoster infections developed in 20 (2.3%) cladribine-treated patients; all cases were dermatomal. There were no herpes zoster infections in the placebo group. Nine (1.0%) patients experienced events related to uterine leiomyomas in the cladribine tablets groups versus one (0.2%) with placebo. Three isolated cases of malignancy were reported in cladribine-treated patients during the study; a fourth was reported during post-study surveillance. A pre-malignant cervical carcinoma in situ was also reported. The incidence of malignancies during the study did not exceed the expected rate in a population standardized for country, gender and age. Conclusion: The safety and tolerability profile observed in the CLARITY study together with the reported efficacy support the potential for cladribine tablets as an MS therapy.
S Cook; P Vermersch; G Comi; G Giovannoni; K Rammohan; P Rieckmann; P Soelberg Sørensen; A Hamlett; M Miret; J Weiner; V Viglietta; B Musch; Sj Greenberg
Related Documents :
20624149 - Step-forward randomization in multicenter emergency treatment clinical trials.
22903779 - New approaches in the treatment of bipolar depression.
22634989 - The management of cyclic vomiting syndrome: a systematic review.
22833649 - Physiotherapy rehabilitation following lumbar spinal fusion: a systematic review and me...
22772569 - Scoliosis specific information on the internet- has the 'information highway' led to be...
22508639 - Adapting cbt for traumatized refugees and ethnic minority patients: examples from cultu...
8350339 - A multicenter study of tenoxicam and diclofenac in patients with osteoarthritis of the ...
3066849 - Trial of ganglioside gm1 in acute stroke.
9046559 - The effects of stressful life events on depression.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-12
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  -     ISSN:  1477-0970     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Predicting the severity of relapsing-remitting MS: the contribution of cross-sectional and short-ter...
Next Document:  Marriage and parenthood among childhood cancer survivors: a report from the Italian AIEOP Off-Therap...