Document Detail


Safety of tienilic acid.
MedLine Citation:
PMID:  388398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The safety and efficacy of tienilic acid have been evaluated in studies of patients with mild to moderate essential hypertension, salt and water retention states and hyperuricaemia associated with gout. During the course of these studies 675 patients were treated with tienilic acid, 310 were treated with hydrochlorothiazide, 43 were treated with probenecid and 34 were treated with placebo. Overall, adverse reactions characterized as probably drug-related or questinably drug-related were reported in 28% of patients treated with tienilic acid, 24% treated with hydrochlorothiazide, 25% of patients treated with probenecid and 33% treated with placebo. The side effects encountered were mild in severity, reversible and represented extensions of the pharmacological activity of tienilic acid, hydrochlorothiazide and probenecid. These initial studies demonstrate that tienilic acid is safe and effective in the treatment of mild to moderate essential hypertension, salt and water retention states, including oedema associated with congestive cardiac failure or mild to moderate renal dysfunction, and in the management of elevated serum uric acid levels associated with gout.
Authors:
M A Beg; R Ragland
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  55 Suppl 3     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1979  
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic
Glycolates / adverse effects*
Heart Failure / drug therapy
Humans
Hydrochlorothiazide / adverse effects,  therapeutic use
Hypertension / blood,  drug therapy
Kidney Diseases / drug therapy
Probenecid / adverse effects,  therapeutic use
Ticrynafen / adverse effects*,  therapeutic use
Uric Acid / blood
Chemical
Reg. No./Substance:
0/Glycolates; 40180-04-9/Ticrynafen; 57-66-9/Probenecid; 58-93-5/Hydrochlorothiazide; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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