| The Safety of sputum induction in adults with acute exacerbation of COPD. | |
| | |
MedLine Citation:
|
PMID: 22452898 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: Induced sputum is a non-invasive method and a useful tool to evaluate inflammatory cells and mediators in the airway lumen in the setting of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD). However, the inhalation of hypertonic saline solution to induce sputum may cause a bronchoconstrictive response, so it is important to evaluate the success and safety of sputum induction. Objectives: The aims of this study were to assess the safety and efficacy of sputum induction (SI) in adults with AECOPD. Methods: 83 AECOPD subjects and 26 healthy controls underwent a modified sputum induction. The outcome measures included fall in lung function during induction and success of sputum induction. Results: Adults hospitalized with AECOPD had moderate to very severe airflow obstruction. Sputum induction was successful in over 80% of subjects. The percentage decrease in FEV(1 ) from baseline by GOLD category was median 1.2(IQR, 0.5-3.3)[GOLD II], 2.3(1.3-3.2)[GOLD III], 5.2(3.3-8.6)[GOLD IV], and 1.4(0.5-3.2)[control], respectively. A fall in FEV(1 ) of > 20% occurred in only one subject with AECOPD who was in GOLD category III. The decrease in percentage of FEV(1) from baseline was greatest in the second stage of induction, and correlated with that of the final stage (r = 0.589; P = 0.01). The fall in FEV(1 ) during induction increased with GOLD category (P < 0.05). Conclusions: SI can be safely and successfully performed in patients with moderate-to-very severe COPD who experience an exacerbation using this modified induction protocol. The early decrease in FEV(1) can be used to predict the maximum fall. © 2012 Blackwell Publishing Ltd. |
| | |
Authors:
|
Peng Gao; Peter G Gibson; Jie Zhang; Xiaoyan He; Yuqiu Hao; Ping Li; Huan Liu |
Related Documents
:
|
21865358 - Effects of simvastatin and metformin on polycystic ovary syndrome after six months of t... 8409568 - A double-blind comparative study of soluble aspirin and diclofenac dispersible in the c... 1548648 - Comparison of controlled-release ketoprofen and diclofenac in the control of post-surgi... 23580058 - Adolescent idiopathic scoliosis treated with posteromedial translation: radiologic eval... 17299908 - Prospective use of euroscore for the short-term risk evaluation of consecutive cardiac ... 20381478 - Immunosuppressive therapy of cyclosporin a for severe benzene-induced haematopoietic di... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-27 |
Journal Detail:
|
Title: The clinical respiratory journal Volume: - ISSN: 1752-699X ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101315570 Medline TA: Clin Respir J Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 Blackwell Publishing Ltd. |
Affiliation:
|
Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun, Jilin, China. Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1 HRMC, Newcastle 2310, Australia, JLU-Woolcock Joint Research Centre for Airway Disease, Changchun, Jilin, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Calcium affects on vascular endpoints.
Next Document: Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans.