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The Safety of sputum induction in adults with acute exacerbation of COPD.
MedLine Citation:
PMID:  22452898     Owner:  NLM     Status:  Publisher    
Introduction:  Induced sputum is a non-invasive method and a useful tool to evaluate inflammatory cells and mediators in the airway lumen in the setting of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD). However, the inhalation of hypertonic saline solution to induce sputum may cause a bronchoconstrictive response, so it is important to evaluate the success and safety of sputum induction. Objectives:  The aims of this study were to assess the safety and efficacy of sputum induction (SI) in adults with AECOPD. Methods:  83 AECOPD subjects and 26 healthy controls underwent a modified sputum induction. The outcome measures included fall in lung function during induction and success of sputum induction. Results:  Adults hospitalized with AECOPD had moderate to very severe airflow obstruction. Sputum induction was successful in over 80% of subjects. The percentage decrease in FEV(1 ) from baseline by GOLD category was median 1.2(IQR, 0.5-3.3)[GOLD II], 2.3(1.3-3.2)[GOLD III], 5.2(3.3-8.6)[GOLD IV], and 1.4(0.5-3.2)[control], respectively. A fall in FEV(1 ) of > 20% occurred in only one subject with AECOPD who was in GOLD category III. The decrease in percentage of FEV(1) from baseline was greatest in the second stage of induction, and correlated with that of the final stage (r = 0.589; P = 0.01). The fall in FEV(1 ) during induction increased with GOLD category (P < 0.05). Conclusions:  SI can be safely and successfully performed in patients with moderate-to-very severe COPD who experience an exacerbation using this modified induction protocol. The early decrease in FEV(1) can be used to predict the maximum fall. © 2012 Blackwell Publishing Ltd.
Peng Gao; Peter G Gibson; Jie Zhang; Xiaoyan He; Yuqiu Hao; Ping Li; Huan Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-27
Journal Detail:
Title:  The clinical respiratory journal     Volume:  -     ISSN:  1752-699X     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101315570     Medline TA:  Clin Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun, Jilin, China. Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1 HRMC, Newcastle 2310, Australia, JLU-Woolcock Joint Research Centre for Airway Disease, Changchun, Jilin, China.
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