| Safety of sentinel node biopsy in breast cancer patients who receive a second radioisotope injection after visualization failure in lymphoscintigraphy. | |
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MedLine Citation:
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PMID: 20976732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: A failure to visualize axillary sentinel nodes in lymphoscintigraphy may lead to an unsuccessful sentinel node biopsy (SNB) and subsequent axillary lymph node dissection (ALND). To avoid unnecessary ALND, a second radioisotope injection may be given but has been considered hazardous. We investigated the axillary recurrence rate after tumor-negative SNB in breast cancer patients who received a second tracer injection after axillary visualization failure in lymphoscintigraphy. METHODS: Altogether 1,309 breast cancer patients who underwent a tumor-negative SNB without an ALND were included. Two hundred seven (15.8%) patients received a second tracer injection due to visualization failure in lymphoscintigraphy and 1,102 (84.2%) did not. All patients received a blue dye injection prior to the SNB. The median follow-up time was 43 months. RESULTS: No isolated cancer recurrences were diagnosed in the ipsilateral axilla among patients who received two radioisotope injections. Disease-free survival and overall survival were similar among patients with one or two radioisotope injections (P = 0.122 and P = 0.200, respectively). CONCLUSIONS: Additional radiocolloid tracer injection after axillary non-visualization in lymphoscintigraphy is safe and does not increase axillary recurrence risk after tumor-negative SNB. The results suggest that such patients can be safely managed with SNB without a need to perform an ALND. |
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Authors:
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Tuomo J Meretoja; Heikki Joensuu; Päivi S Heikkilä; Marjut H Leidenius |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of surgical oncology Volume: 102 ISSN: 1096-9098 ISO Abbreviation: J Surg Oncol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2010-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 649-55 Citation Subset: IM |
Affiliation:
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Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland. tuomo.meretoja@fimnet.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Axilla Breast Neoplasms / pathology* Female Humans Injections / adverse effects* Lymph Nodes / radionuclide imaging* Lymphatic Metastasis / radionuclide imaging* Middle Aged Preoperative Care Radioisotopes / administration & dosage*, adverse effects, diagnostic use Retreatment* Sentinel Lymph Node Biopsy / methods* Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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