Document Detail


Safety of rituximab therapy during the first trimester of pregnancy: a case history.
MedLine Citation:
PMID:  15089769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The optimal treatment of non-Hodgkin's lymphoma (NHL) during pregnancy is currently undefined. The potential teratogenic effects of conventional chemotherapy preclude its use during the first trimester of pregnancy. We report the case of a pregnant woman with relapsed indolent follicular NHL who was treated with rituximab (unintentionally) during the first trimester. The treatment stabilised the disease. Following an uncomplicated pregnancy, a healthy child was born at full term and careful haematological and immunological monitoring has revealed no adverse effects resulting from exposure to rituximab. Data of using rituximab during pregnancy are scarce, but the present case shows that rituximab may be one option for treatment of NHL in early pregnancy.
Authors:
Eva Kimby; Asgerdur Sverrisdottir; Göran Elinder
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of haematology     Volume:  72     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-05-13     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Hematology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden. eva.kimby@swipnet.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Monoclonal / adverse effects,  therapeutic use*
Antimetabolites, Antineoplastic / therapeutic use
Antineoplastic Agents / adverse effects,  therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  therapeutic use
Cisplatin / administration & dosage
Cladribine / therapeutic use
Combined Modality Therapy
Cyclophosphamide / administration & dosage
Cytarabine / administration & dosage
Dexamethasone / administration & dosage
Disease Progression
Doxorubicin / administration & dosage
Etoposide / administration & dosage
Female
Humans
Ifosfamide / administration & dosage
Infant, Newborn
Lymphoma, Follicular / drug therapy*
Male
Methotrexate / administration & dosage
Mitoguazone / administration & dosage
Peripheral Blood Stem Cell Transplantation
Prednisone / administration & dosage
Pregnancy
Pregnancy Complications, Neoplastic / drug therapy*
Pregnancy Outcome
Pregnancy Trimester, First*
Remission Induction
Safety
Transplantation, Autologous
Vincristine / administration & dosage
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antimetabolites, Antineoplastic; 0/Antineoplastic Agents; 0/CHOP protocol; 0/DHAP protocol; 0/MIME protocol; 0/rituximab; 147-94-4/Cytarabine; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 33419-42-0/Etoposide; 3778-73-2/Ifosfamide; 4291-63-8/Cladribine; 459-86-9/Mitoguazone; 50-02-2/Dexamethasone; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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