| Safety profile and efficacy of botulinum toxin A (Dysport) in children with muscle spasticity. | |
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MedLine Citation:
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PMID: 11305399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Botulinum toxin A (BTX-A) is widely used in the management of muscle spasticity in children. However, at present the dose of BTX-A for a given patient is selected empirically. The aim of this study is to provide dosage guidelines that are based on risk/benefit assessment. This was a multicentre retrospective study of the safety profile and efficacy of BTX-A in children with chronic muscle spasticity. Data in 758 patients who received a total of 1594 treatments were analysed (mean age 7.2 years; 429 males, 329 females). Spastic cerebral palsy (CP) was the most common diagnosis (94% of the study sample). Of all treatments 7% resulted in adverse events; incidence was related to the total dose rather than the dose calculated on the basis of body weight. The highest incidence of adverse events was observed in patients who received >1000 IU of BTX-A per treatment session. The odds of an adverse event was 5.1 times greater for this group of patients than for those who had 250 IU or less (p<0.001). A good overall response to treatment was reported in 82% and treatment goals were fully or partially achieved in 3% and 94% of participants respectively. More patients in the highest dose group reported functional deterioration. Interestingly, multilevel treatments resulted in a better response than single-level treatments (odds ratio 1.7, 95% CI 1.3 to 2.2,p=0.001). |
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Authors:
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A M Bakheit; S Severa; A Cosgrove; R Morton; S H Roussounis; L Doderlein; J P Lin; S H Rousso |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 43 ISSN: 0012-1622 ISO Abbreviation: Dev Med Child Neurol Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-17 Completed Date: 2001-05-10 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: England |
Other Details:
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Languages: eng Pagination: 234-8 Citation Subset: IM |
Affiliation:
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University of Plymouth, Beauchamp Centre, Mount Gould Hospital, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Botulinum Toxin Type A / administration & dosage*, adverse effects* Child Child, Preschool Chronic Disease Dose-Response Relationship, Drug Female Humans Male Muscle Spasticity / drug therapy* Neuromuscular Agents / administration & dosage*, adverse effects* Retrospective Studies Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxin Type A; 0/Neuromuscular Agents |
| Comments/Corrections | |
Erratum In:
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Dev Med Child Neurol 2001 May;43(5):357 Note: Rousso SH [corrected to Roussounis SH] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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