Document Detail

Safety of perioperative β-blocker use: how do β-blockers compare in terms of side effects?
MedLine Citation:
PMID:  21247365     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: In the perioperative setting, there is still a high incidence of adverse cardiac events due to sudden coronary plaque rupture or oxygen supply-demand imbalance. β-Blockers play an important role in preventing these cardiac events. Discussion, however, remains on the side effects accompanying this therapy.
AREAS COVERED: The evidence for perioperative use of β-blockers is summarized in this review in terms of risk reduction, perioperative safety and current clinical use. Furthermore, data on pharmacokinetics, pharmacodynamics and pharmacogenetics are presented.
EXPERT OPINION: In perioperative care, β-blockers are recommended and can be given safely when started early in a low dose, titrated to heart rate. In the future, there could be a place for added perioperative short-acting β-blockers to further optimize heart rate control.
Niels J C Ravensbergen; Michiel T Voute; Don Poldermans
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-01-20
Journal Detail:
Title:  Expert opinion on drug safety     Volume:  10     ISSN:  1744-764X     ISO Abbreviation:  Expert Opin Drug Saf     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-13     Completed Date:  2012-05-07     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101163027     Medline TA:  Expert Opin Drug Saf     Country:  England    
Other Details:
Languages:  eng     Pagination:  545-58     Citation Subset:  IM    
Erasmus Medical Centre, Department of Vascular Surgery, Rotterdam, The Netherlands.
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MeSH Terms
Adrenergic beta-Antagonists / administration & dosage*,  adverse effects*,  metabolism
Heart Rate / drug effects,  physiology
Perioperative Care / methods*,  standards
Randomized Controlled Trials as Topic / methods
Receptors, Adrenergic, beta-1 / metabolism
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, beta-1

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