Document Detail

Safety of percutaneous liver biopsy in infants less than three months old.
MedLine Citation:
PMID:  16254523     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the safety, outcomes, and complications of percutaneous liver biopsies (PLB) in infants aged 0 to 3 months. METHODS: We retrospectively reviewed the hospital records of all infants less than 3 months old who underwent PLB at Children's Memorial Hospital between July 1, 1997 and June 30, 2004 for complications surrounding the procedure and risk factors that might lead to complications. RESULTS: Sixty-six PLBs were performed in 63 infants. Most patients tolerated the procedure without complications. Twelve complications were recorded, for an overall complication rate of 18%. Of these, five were directly related to the procedure, and seven were sedation related. Three patients experienced a drop in hemoglobin greater than 2 gm/dL, one patient developed a bile leak, and one developed a skin hematoma. Seven patients had respiratory difficulty related to sedation, which manifested as increased work of breathing or decreased respiratory rate with depression in pulse oximetry. CONCLUSION: We conclude that PLB in young infants is associated with a somewhat higher risk of complications than in older children, particularly complications related to sedation.
R K Azzam; E M Alonso; K M Emerick; P F Whitington
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  41     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-28     Completed Date:  2006-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  639-43     Citation Subset:  IM    
Department of Pediatrics, Children's Memorial Hospital, Northwestern University Feinberg Medical School, Chicago, Illinois 60614, USA.
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MeSH Terms
Bile Ducts / injuries
Biopsy / adverse effects*,  methods
Biopsy, Needle / adverse effects*,  methods
Gestational Age
Hematoma / etiology
Hemoglobins / analysis
Hemorrhage / etiology
Hypnotics and Sedatives / administration & dosage,  adverse effects*
Infant, Newborn
Meperidine / administration & dosage,  adverse effects*
Midazolam / administration & dosage,  adverse effects*
Respiration / drug effects
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Hemoglobins; 0/Hypnotics and Sedatives; 57-42-1/Meperidine; 59467-70-8/Midazolam

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