Document Detail

Safety of outpatient dalteparin therapy in veterans with mechanical heart valves.
MedLine Citation:
PMID:  16232019     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: To determine the rate of bleeding and thromboembolic events within 1 month of outpatient dalteparin therapy in veterans with mechanical heart valves, to evaluate potential risk factors associated with these events, and to examine the prescribing patterns of dalteparin in this patient population. DESIGN: Single-center retrospective electronic chart review. SETTING: Large, academically affiliated Veterans Affairs hospital. SUBJECTS: Thirty-eight men with mechanical heart valves who received outpatient prescriptions for dalteparin from October 1, 1998-June 30, 2003. MEASUREMENTS AND MAIN RESULTS: Charts were reviewed for thromboembolic and bleeding events. Demographic, clinical, and drug utilization variables were assessed. The associations of adverse events with potential risk factors, indication for dalteparin therapy, and prescribing clinic were analyzed. Sixty-four dalteparin regimens were evaluated. No thromboembolic events were reported in any case within 1 month after receiving dalteparin for thromboembolic prophylaxis during warfarin interruption for periprocedural anticoagulation or for anticoagulation during an unintentional subtherapeutic international normalized ratio. Bleeding events occurred in 15 (23%) of the 64 regimens. Most bleeding events resolved spontaneously and without intervention. No potential risk factors for bleeding were identified. CONCLUSION: Dalteparin appeared to be a safe, effective means of short-term thromboembolic prophylaxis in this population of ambulatory male veterans with mechanical heart valves. Large, randomized, controlled, prospective trials are warranted.
Jessica L O'Neill; Petra S Flanagan; Carolyn R Zaleon; Laurel A Copeland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  25     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-19     Completed Date:  2006-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1560-5     Citation Subset:  IM    
Department of Pharmacy, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA.
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MeSH Terms
Aged, 80 and over
Anticoagulants / adverse effects*
Dalteparin / adverse effects*
Heart Valve Prosthesis*
Hemorrhage / chemically induced
Middle Aged
Thromboembolism / prevention & control*
Reg. No./Substance:
0/Anticoagulants; 0/Dalteparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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