| Safety of oral glutamine in the abbreviation of preoperative fasting: a double-blind, controlled, randomized clinical trial. | |
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MedLine Citation:
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PMID: 21519733 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: No study so far has tested a beverage containing glutamine 2 h before anesthesia in patients undergoing surgery. Objectives: The aim of the study was to investigate: 1) the safety of the abbreviation of preoperative fasting to 2 h with a carbohydrate-L-glutamine-rich drink; and 2) the residual gastric volume (RGV) measured after the induction of anesthesia for laparoscopic cholecystectomies. Methods: Randomized controlled trial with 56 women (42 (17-65) years-old) submitted to elective laparoscopic cholecystectomy. Patients were randomized to receive either conventional preoperative fasting of 8 hours (fasted group, n = 12) or one of three different beverages drunk in the evening before surgery (400 mL) and 2 hours before the initiation of anesthesia (200 mL). The beverages were water (placebo group, n = 12), 12.5% (240 mOsm/L) maltodextrine (carbohydrate group, n = 12) or the latter in addition to 50 g (40 g in the evening drink and 10g in the morning drink) of L-glutamine (glutamine group, n = 14). A 20 F nasogastric tube was inserted immediately after the induction of general anesthesia to aspirate and measure the RGV. Results: Fifty patients completed the study. None of the patients had either regurgitation during the induction of anesthesia or postoperative complications. The median (range) of RGV was 6 (0-80) mL. The RGV was similar (p = 0.29) between glutamine group (4.5 [0-15] mL), carbohydrate group (7.0 [0-80] mL), placebo group (8.5 [0-50] mL), and fasted group (5.0 [0-50] mL). Conclusion: The abbreviation of preoperative fasting to 2 h with carbohydrate and L-glutamine is safe and does not increase the RGV during induction of anesthesia. |
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Authors:
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D Borges Dock-Nascimento; J E D Aguilar-Nascimento; C Caporossi; M Sepulveda Magalhães Faria; R Bragagnolo; F S Caporossi; D Linetzky Waitzberg |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Nutricion hospitalaria : organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral Volume: 26 ISSN: 1699-5198 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100365 Medline TA: Nutr Hosp Country: - |
Other Details:
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Languages: ENG Pagination: 86-90 Citation Subset: - |
Affiliation:
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Department of Food and Nutrition, Federal University of Mato Grosso, Cuiabá, Brazil. |
Vernacular Title:
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Seguridad de la glutamina oral en la abreviación del ayuno preoperatorio: un ensayo clínico doble ciego, controlado, aleatorizado. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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