Document Detail

Safety of oral glutamine in the abbreviation of preoperative fasting: a double-blind, controlled, randomized clinical trial.
MedLine Citation:
PMID:  21519733     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: No study so far has tested a beverage containing glutamine 2 h before anesthesia in patients undergoing surgery.
OBJECTIVES: The aim of the study was to investigate: 1) the safety of the abbreviation of preoperative fasting to 2 h with a carbohydrate-L-glutamine-rich drink; and 2) the residual gastric volume (RGV) measured after the induction of anesthesia for laparoscopic cholecystectomies.
METHODS: Randomized controlled trial with 56 women (42 (17-65) years-old) submitted to elective laparoscopic cholecystectomy. Patients were randomized to receive either conventional preoperative fasting of 8 hours (fasted group, n = 12) or one of three different beverages drunk in the evening before surgery (400 mL) and 2 hours before the initiation of anesthesia (200 mL). The beverages were water (placebo group, n = 12), 12.5% (240 mOsm/L) maltodextrine (carbohydrate group, n = 12) or the latter in addition to 50 g (40 g in the evening drink and 10 g in the morning drink) of L-glutamine (glutamine group, n = 14). A 20 F nasogastric tube was inserted immediately after the induction of general anesthesia to aspirate and measure the RGV.
RESULTS: Fifty patients completed the study. None of the patients had either regurgitation during the induction of anesthesia or postoperative complications. The median (range) of RGV was 6 (0-80) mL. The RGV was similar (p = 0.29) between glutamine group (4.5 [0-15] mL), carbohydrate group (7.0 [0-80] mL), placebo group (8.5 [0-50] mL), and fasted group (5.0 [0-50] mL).
CONCLUSION: The abbreviation of preoperative fasting to 2 h with carbohydrate and L-glutamine is safe and does not increase the RGV during induction of anesthesia.
D Borges Dock-Nascimento; J E D Aguilar-Nascimento; C Caporossi; M Sepulveda Magalhães Faria; R Bragagnolo; F Stephan Caporossi; D Linetzky Waitzberg
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Nutrición hospitalaria     Volume:  26     ISSN:  1699-5198     ISO Abbreviation:  Nutr Hosp     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-04-26     Completed Date:  2011-09-01     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9100365     Medline TA:  Nutr Hosp     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
Department of Food and Nutrition, Federal University of Mato Grosso, Cuiabá, Brazil.
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MeSH Terms
Cholecystectomy, Laparoscopic
Dietary Carbohydrates / therapeutic use
Double-Blind Method
Fasting / physiology*
Glutamine / adverse effects*,  therapeutic use
Middle Aged
Preoperative Period*
Sample Size
Stomach / anatomy & histology
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Dietary Carbohydrates; 56-85-9/Glutamine

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