| Safety of occluded 4% liposomal lidocaine cream. | |
| | |
MedLine Citation:
|
PMID: 16865866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The use of topical anesthesia for pain control for dermatologic procedures is widespread. In addition to clinical procedures, such as skin biopsies, lesion removal, and electrocautery, topical anesthesia is used for pain control in a variety of cutaneous cosmetic procedures including laser procedures and injection of filler substances and/or botulism toxin. While the use of topical anesthesia is generally regarded as safe and effective, recent concern about lidocaine toxicity from the use of compounded mixtures of lidocaine for cosmetic procedures has been reported. This study evaluated the potential absorption and clinical toxicity of either 30 or 60 grams of occluded topical liposomal lidocaine (LMX4) in 8 healthy volunteers. Blood was drawn to evaluate levels of lidocaine and monoethylglycinexylidide (MEGX) metabolites prior to application of the occluded cream at 1 hour, 2 hours, 6 hours, and 24 hours post-application. Additionally, the volunteers were assessed for any clinical signs of lidocaine toxicity. All blood samples showed less than 0.5 mcg/mL of serum lidocaine and MEGX metabolite. Patients reported no systemic effects and did not show any clinical signs of lidocaine toxicity. Conclusions were that moderate amounts (30 and 60 grams-amounts used in a variety of cosmetic procedures) of occluded 4% lidocaine cream were safe; the test subjects showed no evidence of clinical toxicity and blood levels showed no evidence of significant lidocaine or lidocaine metabolites. |
| | |
Authors:
|
Mark S Nestor |
Related Documents
:
|
19870386 - The relation between the type specific carbohydrates of pneumococci and the blood group... 1375596 - Effect of neuropeptides released from sensory nerves on blood flow in the rat airway mi... 6185916 - Increased myometrial blood flow evoked by substance p. 19867956 - An experimental study of blood glycolysis. the effects of thyroid and adrenal extracts ... 12395896 - Intestinal blood flow in murine colitis induced with dextran sulfate sodium. 753626 - Cerebral metabolic, hemodynamic and antihypoxic properties of l-eburnamonine. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of drugs in dermatology : JDD Volume: 5 ISSN: 1545-9616 ISO Abbreviation: J Drugs Dermatol Publication Date: 2006 Jul-Aug |
Date Detail:
|
Created Date: 2006-07-26 Completed Date: 2006-11-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101160020 Medline TA: J Drugs Dermatol Country: United States |
Other Details:
|
Languages: eng Pagination: 618-20 Citation Subset: IM |
Affiliation:
|
Center for Cosmetic Enhancement, Aventura Florida and University of Miami Miller School of Medicine, Department of Dermatology and Continuous Surgery, Miami, FL, USA. nestormd@admcorp.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthetics, Local
/
administration & dosage,
therapeutic use Biopsy / adverse effects Dosage Forms Humans Lidocaine / administration & dosage, therapeutic use* Liposomes Pain Safety |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Local; 0/Dosage Forms; 0/Liposomes; 137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical evaluation of fluid extract of Chamomilla recutita for oral aphthae.
Next Document: Alefacept in combination with ultraviolet B phototherapy for the treatment of chronic plaque psorias...