Document Detail

Safety of newer generation anti-epileptic drugs in non-accidental overdose: an Irish population study.
MedLine Citation:
PMID:  15797348     Owner:  NLM     Status:  MEDLINE    
METHOD: All reported cases of drug overdoses with AEDs from 1996 to 2000 were reviewed. Data was provided by the National Poisons Information Centre, Beaumont Hospital and the Central Statistics Office. Medical records from Beaumont Hospital were reviewed in specific cases of serious drug toxicities. An extensive review of published literature reviewing the safety profile of these AEDs was performed and medical literature retrieved from the databases of the pharmaceutical industry was similarly reviewed.
RESULTS: Of the 164 reported cases of newer AEDs, there were no fatalities among the cases followed up.
CONCLUSION: The absence of mortalities and serious consequences from deliberate self-poisoning with the newer agents is supportive evidence for the superior safety profile of the newer AEDs.
S Sukumaran; J Herbert; J Tracey; N Delanty
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seizure     Volume:  14     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-30     Completed Date:  2005-06-06     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  151-6     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / adverse effects,  therapeutic use*
Drug Evaluation
Drug Overdose
Epilepsy / drug therapy*,  epidemiology
Ireland / epidemiology
Population Surveillance / methods*
Retrospective Studies
Review Literature as Topic
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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