Document Detail

Safety of a new transpulmonary echocontrast agent (Albunex) in repeated echocardiographic studies in patients.
MedLine Citation:
PMID:  9034639     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND HYPOTHESIS: Multiple contrast-enhanced echocardiographic studies are to be expected in patients with cardiac ischemic disease, but the sonication process used to produce the echocontrast agent Albunex may result in new epitopes that could cause an immunogenic response. METHODS: Repeated exposures to intravenous Albunex over a period of time long enough to allow development of an eventual immune reaction were performed in 12 patients while monitoring for lymphocyte transformation, microsphere specific IgE and IgG antibodies, and systemic, pulmonary artery, capillary wedge, and right atrial pressures, as well as cardiac output, left ventricular fractional shortening, and blood gases. RESULTS: No significant 3H-thymidine incorporation and thus no specific blastic transformation of the patients' lymphocytes were observed either for high or low Albunex concentrations, corresponding to the expected hepatic and plasma concentrations of microspheres. No formation of microsphere-specific IgE and IgG antibodies was observed after the first or second Albunex exposure. Furthermore, no clinically significant hemodynamic or respiratory adverse reactions were observed in any patient. CONCLUSION: These results suggest that repeated exposures to intravenous Albunex induce no adverse effect on the cellular and humoral immune systems and on left and right heart hemodynamics in patients.
B Geny; P Bischoff; B Muan; F Piquard; J C Thiranos; E Epailly; M Lambrechs; A Juelsrud-Vebner; B Eisenmann; P Haberey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  20     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-29     Completed Date:  1997-04-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  111-5     Citation Subset:  IM    
Laboratoire d'Explorations Fonctionnelles du Système Circulatoire, Faculté de Médecine, Université Louis Pasteur, Strasbourg, France.
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MeSH Terms
Albumins / adverse effects,  diagnostic use*,  immunology
Contrast Media*
Echocardiography / methods*
Heart Catheterization
Hemodynamics / drug effects
Immunoglobulin E / analysis
Immunoglobulin G / analysis
Infusions, Intravenous
Lymphocyte Activation / immunology
Lymphocytes / immunology
Middle Aged
Myocardial Ischemia / immunology,  ultrasonography*
Pulmonary Circulation / drug effects
Reg. No./Substance:
0/Albumins; 0/Albunex; 0/Contrast Media; 0/Immunoglobulin G; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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