| Safety of morphine in nonintubated infants in the neonatal intensive care unit. | |
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MedLine Citation:
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PMID: 19454876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the safety of morphine for procedural pain management in nonintubated infants in the neonatal intensive care unit. METHODS: Retrospective cohort study comparing nonintubated infants undergoing central line placement who received morphine during the procedure with a sex and age-matched group who did not receive morphine. The incidence of clinically significant respiratory depression and hypotension, defined as requiring intervention (ie, bag/mask ventilation, increased ventilatory support, and naloxone reversal for respiratory depression and saline volume expansion and inotropes for hypotension), were compared between groups using chi test. RESULTS: There were no differences (P>0.05) between morphine (N=43) and no morphine (N=43) groups in gestational age [34.2 (4.6) vs. 34.6 (3.8) wk; P=0.63], postnatal age [13.7 (22.6) vs. 12.3 (15) wk; P=0.73], and weight [2.3 kg (0.9) for both groups]. Five (11.6%) morphine-treated infants experienced respiratory depression compared with none (0%) in the no morphine group (P=0.02); removal of 2 overdosed infants in the morphine group reduced the incidence to 7.3%, which was not significantly different from 0% in the no morphine group (P=0.07). There were no cases of hypotension. CONCLUSIONS: Morphine administration was associated with respiratory depression but not hypotension when administered to nonintubated infants undergoing central line placement. Morphine should be used with caution in this population. |
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Authors:
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Anna Taddio; Blondel Crosdale; Mary-Ellen Hogan; Manal F El Sayed; Kyong-Soon Lee; Aideen M Moore; Vibhuti Shah |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Clinical journal of pain Volume: 25 ISSN: 1536-5409 ISO Abbreviation: Clin J Pain Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-20 Completed Date: 2009-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8507389 Medline TA: Clin J Pain Country: United States |
Other Details:
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Languages: eng Pagination: 418-22 Citation Subset: IM |
Affiliation:
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Pharmacy Practice Division, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada. anna.taddio@utoronto.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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therapeutic use Comorbidity Female Humans Hypotension / diagnosis, epidemiology* Incidence Infant, Newborn Intensive Care Units, Neonatal / statistics & numerical data* Intubation / statistics & numerical data Male Morphine / therapeutic use* Ontario / epidemiology Pain / epidemiology*, prevention & control* Respiratory Insufficiency / diagnosis, epidemiology* Retrospective Studies Risk Assessment / methods Risk Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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