| Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma. | |
| | |
MedLine Citation:
|
PMID: 20964595 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Object The authors assessed the safety and maximum tolerated dose of superselective intraarterial cerebral infusion (SIACI) of bevacizumab after osmotic disruption of the blood-brain barrier (BBB) with mannitol in patients with recurrent malignant glioma. Methods A total of 30 patients with recurrent malignant glioma were included in the current study. Results The authors report no dose-limiting toxicity from a single dose of SIACI of bevacizumab up to 15 mg/kg after osmotic BBB disruption with mannitol. Two groups of patients were studied; those without prior bevacizumab exposure (naïve patients; Group I) and those who had received previous intravenous bevacizumab (exposed patients; Group II). Radiographic changes demonstrated on MR imaging were assessed at 1 month postprocedure. In Group I patients, MR imaging at 1 month showed a median reduction in the area of tumor enhancement of 34.7%, a median reduction in the volume of tumor enhancement of 46.9%, a median MR perfusion (MRP) reduction of 32.14%, and a T2-weighted/FLAIR signal decrease in 9 (47.4%) of 19 patients. In Group II patients, MR imaging at 1 month showed a median reduction in the area of tumor enhancement of 15.2%, a median volume reduction of 8.3%, a median MRP reduction of 25.5%, and a T2-weighted FLAIR decrease in 0 (0%) of 11 patients. Conclusions The authors conclude that SIACI of mannitol followed by bevacizumab (up to 15 mg/kg) for recurrent malignant glioma is safe and well tolerated. Magnetic resonance imaging shows that SIACI treatment with bevacizumab can lead to reduction in tumor area, volume, perfusion, and T2-weighted/FLAIR signal. |
| | |
Authors:
|
John A Boockvar; Apostolos J Tsiouris; Christoph P Hofstetter; Ilhami Kovanlikaya; Sherese Fralin; Kartik Kesavabhotla; Stephen M Seedial; Susan C Pannullo; Theodore H Schwartz; Philip Stieg; Robert D Zimmerman; Jared Knopman; Ronald J Scheff; Paul Christos; Shankar Vallabhajosula; Howard A Riina |
Related Documents
:
|
3101475 - Optimizing mr imaging for detecting small tumors in the cerebellopontine angle and inte... 16272865 - Magnetic resonance imaging findings of angiosarcoma of the scalp. 16274265 - Advanced magnetic resonance imaging techniques to evaluate cns glioma. 9798875 - Using mr imaging to predict and evaluate the response of invasive cervical carcinoma to... 8088035 - Staging, volume estimation and assessment of nodal status in carcinoma of the cervix: c... 9106775 - Quantitative scintigraphic analysis of 123i-mibg by polar map in patients with dilated ... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-22 |
Journal Detail:
|
Title: Journal of neurosurgery Volume: 114 ISSN: 1933-0693 ISO Abbreviation: J. Neurosurg. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
|
Languages: eng Pagination: 624-32 Citation Subset: AIM; IM |
Affiliation:
|
Departments of Neurosurgery. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intraoperative magnetic resonance imaging-guided tractography with integrated monopolar subcortical ...
Next Document: Reconstructive endovascular treatment of intracranial aneurysms with the Willis covered stent: mediu...