Document Detail


Safety of low-molecular-weight heparin during pregnancy: a retrospective controlled cohort study.
MedLine Citation:
PMID:  22658765     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To study the safety of low-molecular-weight heparin (LMWH) treatment during pregnancy for the mother and the foetus. STUDY DESIGN: Retrospective controlled cohort study. Six hundred and forty-eight pregnancies exposed to LMWH were compared with 626 unexposed pregnancies. Principal characteristics, indications for LMWH use, and maternal and foetal complications were reported for each pregnancy. Data were obtained from patients' electronic hospital records and analysed using Statistical Package for the Social Sciences Version 17.0. RESULTS: The incidence rates of various pregnancy complications did not differ between the groups (LMWH group vs control group): 1.56% vs 1.1% for thrombocytopenia, 8.7% vs 6.5% for preterm delivery, 0.7% vs 0.3% for stillbirth, 1.4% vs 1.0% for severe pre-eclampsia, 2.7% vs 2.2% for foetal growth restriction, and 10.7% vs 7.8% for antenatal bleeding. One serious antenatal maternal haemorrhage occurred in the LMWH group (0.15%), but this was unrelated to LMWH use. The caesarean section rate and the amount of bleeding during delivery were similar in the two groups (21% vs 19% and 500 vs 450ml, respectively). The risk of major blood loss during labour (>1000ml) was no higher in the LMWH group compared with the control group. The incidence of allergic skin reactions was 0.3% in the LMWH group. No heparin-induced thrombocytopenia or symptomatic osteoporotic fractures were observed. Recurrent venous thromboembolic events occurred in 2.5% of patients in the LMWH group. CONCLUSION: This study indicates that the use of LMWH is safe during pregnancy.
Authors:
Päivi J Galambosi; Risto J Kaaja; Vedran Stefanovic; Veli-Matti Ulander
Related Documents :
7137445 - The detection of circulating immune complexes and igg and igm rheumatoid factors in nor...
15519425 - Prevention and management of rhd isoimmunization.
637095 - Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. iv. the ...
19876825 - The hidden maternal-fetal interface: events involving the lymphoid organs in maternal-f...
19445815 - Manipulative therapy for pregnancy and related conditions: a systematic review.
7927695 - Effects of a porphyromonas gingivalis infection on inflammatory mediator response and p...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-1
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  -     ISSN:  1872-7654     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dosimetric comparison between two MLC systems commonly used for stereotactic radiosurgery and radiot...
Next Document:  Leptin drives fat distribution during diet-induced obesity in mice.