| Safety of low-dose oral dantrolene sodium on hepatic function. | |
| | |
MedLine Citation:
|
PMID: 21878205 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the incidence of hepatobiliary dysfunction after administration of low-dose dantrolene sodium. DESIGN: A retrospective survey of medical records. SETTING: One secondary and 2 tertiary hospitals. PARTICIPANTS: Patients (N=243; 144 men, 27 children; mean age ± SD, 47.8±19.7y) who were administered dantrolene at a daily dose of 12.5 to 400mg for more than 4 weeks. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Liver function test (LFT) results, including serum total bilirubin, aspartate transaminase, alanine transaminase, and alkaline phosphatase, were recorded before and at least 1 month after the initial dose of dantrolene. In cases of treatment cessation, the reason was investigated. Significantly elevated LFT levels were defined as ≥ to 2 times the upper limit of the normal range. RESULTS: Treatment duration was 268.0±428.5 days with a daily dose of 65.2±44.7mg. At the end of the investigation, 95 patients (39.1%) had been lost to follow-up, and 105 (43.2%) had stopped treatment. The reasons for cessation were improved spasticity (42.9%), no effect of the medication (27.6%), weakness (6.7%), and other medical problems (5.7%). Patients with weaknesses did not have elevated LFT values. A 32-year-old man with head injuries and multiple trauma developed hepatic dysfunction 82 days after the initial dose and 43 days after a dose increment to 400mg/d. Other patients did not experience significant LFT abnormalities. CONCLUSIONS: One case of hepatic dysfunction was recorded in 243 cases after at least 4 weeks of low-dose oral dantrolene administration. Low-dose dantrolene can be used safely with meticulous clinical and laboratory monitoring. |
| | |
Authors:
|
Jung Yoon Kim; Sewoong Chun; Moon Suk Bang; Hyung-Ik Shin; Shi-Uk Lee |
Related Documents
:
|
235395 - Antiarrhythmic activity of four pteridine compounds in ouabain intoxication. 21928635 - Evaluation of the dosimetric impact of interfractional anatomical variations on prostat... 9356305 - Toxicity of cordycepin in combination with the adenosine deaminase inhibitor 2'-deoxyco... 8250405 - Circulating concentration of dexamethasone in healthy dogs, dogs with hyperadrenocortic... 2114125 - Differential effects of agents enhancing purinergic transmission upon the antielectrosh... 19610285 - An approach to using conventional brachytherapy software for clinical treatment plannin... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives of physical medicine and rehabilitation Volume: 92 ISSN: 1532-821X ISO Abbreviation: Arch Phys Med Rehabil Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985158R Medline TA: Arch Phys Med Rehabil Country: United States |
Other Details:
|
Languages: eng Pagination: 1359-63 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of burst-type transcutaneous electrical nerve stimulation on cervical range of motion and la...
Next Document: Tongue-based biofeedback for balance in stroke: results of an 8-week pilot study.