Document Detail

Safety of lidocaine 15% and prilocaine 5% topical ointment used as local anesthesia for intense pulsed light treatment.
MedLine Citation:
PMID:  20653728     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Literature cautions against applying lidocaine 15%/prilocaine 5% over an area larger than 300 cm(2). The area of the face, neck, and chest is 400 cm(2) or greater. OBJECTIVE: To investigate the safety of lidocaine 15%/prilocaine 5% topical anesthetic ointment used as anesthesia for intense pulsed light (IPL) treatment. METHODS AND MATERIALS: Lidocaine 15%/prilocaine 5% ointment was applied to the face only (n=10) for 30 +/- 15 minutes or to the face, neck, and chest (n=10) for a total of 60 +/- 15 minutes before IPL. Blood lidocaine and prilocaine levels were measured. Adverse events were recorded. RESULTS: For the entire cohort, blood was drawn 25.6 +/- 6.6 minutes after IPL was completed. In the face only group, the mean lidocaine level was 0.122 +/- 0.125 microg/mL, and the mean prilocaine level was 0.048 +/- 0.029 microg/mL. In the face, neck, and chest group, the mean lidocaine level was 0.272 +/- 0.208 microg/mL, and the mean prilocaine level was 0.087 +/- 0.060 microg/mL. No adverse events related to systemic toxicity were observed or reported to the nurse. At the 24-hour follow-up, no subject reported symptoms of systemic toxicity after leaving the clinic. CONCLUSION: Under the conditions of this study, topical lidocaine 15%/prilocaine 5% produces low levels of systemic absorption.
J Alastair Carruthers; Jean D A Carruthers; Judith Poirier; Heather S Oliff; Julie Mordaunt; William E Schreiber
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  36     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1130-7     Citation Subset:  IM    
Carruthers Dermatology Centre, Inc., Vancouver, BC, Canada.
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MeSH Terms
Administration, Cutaneous
Anesthesia, Local*
Anesthetics, Local / administration & dosage,  adverse effects*
Cosmetic Techniques
Lidocaine / administration & dosage,  adverse effects*
Middle Aged
Pain / diagnosis,  etiology,  prevention & control*
Phototherapy / adverse effects*
Pilot Projects
Prilocaine / administration & dosage,  adverse effects*
Skin Aging
Young Adult
Reg. No./Substance:
0/Anesthetics, Local; 0/Ointments; 137-58-6/Lidocaine; 721-50-6/Prilocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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