| Safety of lidocaine 15% and prilocaine 5% topical ointment used as local anesthesia for intense pulsed light treatment. | |
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MedLine Citation:
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PMID: 20653728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Literature cautions against applying lidocaine 15%/prilocaine 5% over an area larger than 300 cm(2). The area of the face, neck, and chest is 400 cm(2) or greater. OBJECTIVE: To investigate the safety of lidocaine 15%/prilocaine 5% topical anesthetic ointment used as anesthesia for intense pulsed light (IPL) treatment. METHODS AND MATERIALS: Lidocaine 15%/prilocaine 5% ointment was applied to the face only (n=10) for 30 +/- 15 minutes or to the face, neck, and chest (n=10) for a total of 60 +/- 15 minutes before IPL. Blood lidocaine and prilocaine levels were measured. Adverse events were recorded. RESULTS: For the entire cohort, blood was drawn 25.6 +/- 6.6 minutes after IPL was completed. In the face only group, the mean lidocaine level was 0.122 +/- 0.125 microg/mL, and the mean prilocaine level was 0.048 +/- 0.029 microg/mL. In the face, neck, and chest group, the mean lidocaine level was 0.272 +/- 0.208 microg/mL, and the mean prilocaine level was 0.087 +/- 0.060 microg/mL. No adverse events related to systemic toxicity were observed or reported to the nurse. At the 24-hour follow-up, no subject reported symptoms of systemic toxicity after leaving the clinic. CONCLUSION: Under the conditions of this study, topical lidocaine 15%/prilocaine 5% produces low levels of systemic absorption. |
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Authors:
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J Alastair Carruthers; Jean D A Carruthers; Judith Poirier; Heather S Oliff; Julie Mordaunt; William E Schreiber |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Volume: 36 ISSN: 1524-4725 ISO Abbreviation: Dermatol Surg Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504371 Medline TA: Dermatol Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1130-7 Citation Subset: IM |
Affiliation:
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Carruthers Dermatology Centre, Inc., Vancouver, BC, Canada. alastair@carruthers.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adult Aged Anesthesia, Local* Anesthetics, Local / administration & dosage, adverse effects* Cosmetic Techniques Face Female Humans Lidocaine / administration & dosage, adverse effects* Male Middle Aged Neck Ointments Pain / diagnosis, etiology, prevention & control* Phototherapy / adverse effects* Pilot Projects Prilocaine / administration & dosage, adverse effects* Skin Aging Thorax Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Ointments; 137-58-6/Lidocaine; 721-50-6/Prilocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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