| Safety of ketoprofen in the elderly: a prospective study on 20,000 patients. | |
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MedLine Citation:
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PMID: 2697083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Safety is a major concern in drug therapy in the elderly. NSAIDs are often used in the elderly and may induce side-effects. With a view to monitor the safety profile of ketoprofen, 19,880 patients greater than 60 years of age were enrolled in a large scale open study. They received a 200 mg sustained release tablet once-a-day for one month, in almost all cases for osteoarthritis. Patients mean age was 72.2 +/- 6.7 years. At the end of treatment, overall efficacy was rated as excellent or good in 70.7% of cases by patients and 74.2% by physicians. Tolerability was judged excellent: 60.8%; good: 24.0%; moderate: 8.7%; and poor: 5.1%. Side-effects related to ketoprofen occurred in 15.3% of patients and led to withdrawal in 4.5%. The most frequent side-effects were related to the G.I. tract (13.5% of total patients). Severe G.I. side-effects (ulcer, melena) occurred in 0.03%. Skin side-effects occurred in 0.7% and were always benign. No relationship was found between the incidence of side-effects and age or dosing time. In contrast, a higher incidence of side-effects was demonstrated in women, in case of associated disorders or concomitant therapy and in patients previously treated with other NSAIDs. In conclusion, in this very large population of elderly patients, ketoprofen had a good risk/benefit ratio. |
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Authors:
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X Le Loet |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Scandinavian journal of rheumatology. Supplement Volume: 83 ISSN: 0301-3847 ISO Abbreviation: Scand. J. Rheumatol. Suppl. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-04-05 Completed Date: 1990-04-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400360 Medline TA: Scand J Rheumatol Suppl Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 21-7 Citation Subset: IM |
Affiliation:
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Dept of Rheumatology, C.H.U. Rouen, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Gastrointestinal Diseases / chemically induced Humans Ketoprofen / adverse effects, therapeutic use* Male Multicenter Studies as Topic Multivariate Analysis Prospective Studies Rheumatic Diseases / drug therapy* Skin Diseases / chemically induced |
| Chemical | |
Reg. No./Substance:
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22071-15-4/Ketoprofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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