Document Detail

Safety of ketoprofen in the elderly: a prospective study on 20,000 patients.
MedLine Citation:
PMID:  2697083     Owner:  NLM     Status:  MEDLINE    
Safety is a major concern in drug therapy in the elderly. NSAIDs are often used in the elderly and may induce side-effects. With a view to monitor the safety profile of ketoprofen, 19,880 patients greater than 60 years of age were enrolled in a large scale open study. They received a 200 mg sustained release tablet once-a-day for one month, in almost all cases for osteoarthritis. Patients mean age was 72.2 +/- 6.7 years. At the end of treatment, overall efficacy was rated as excellent or good in 70.7% of cases by patients and 74.2% by physicians. Tolerability was judged excellent: 60.8%; good: 24.0%; moderate: 8.7%; and poor: 5.1%. Side-effects related to ketoprofen occurred in 15.3% of patients and led to withdrawal in 4.5%. The most frequent side-effects were related to the G.I. tract (13.5% of total patients). Severe G.I. side-effects (ulcer, melena) occurred in 0.03%. Skin side-effects occurred in 0.7% and were always benign. No relationship was found between the incidence of side-effects and age or dosing time. In contrast, a higher incidence of side-effects was demonstrated in women, in case of associated disorders or concomitant therapy and in patients previously treated with other NSAIDs. In conclusion, in this very large population of elderly patients, ketoprofen had a good risk/benefit ratio.
X Le Loet
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Scandinavian journal of rheumatology. Supplement     Volume:  83     ISSN:  0301-3847     ISO Abbreviation:  Scand. J. Rheumatol. Suppl.     Publication Date:  1989  
Date Detail:
Created Date:  1990-04-05     Completed Date:  1990-04-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400360     Medline TA:  Scand J Rheumatol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Dept of Rheumatology, C.H.U. Rouen, France.
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MeSH Terms
Gastrointestinal Diseases / chemically induced
Ketoprofen / adverse effects,  therapeutic use*
Multicenter Studies as Topic
Multivariate Analysis
Prospective Studies
Rheumatic Diseases / drug therapy*
Skin Diseases / chemically induced
Reg. No./Substance:

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