Document Detail

Safety and impact of vitamin A supplementation delivered with oral polio vaccine as part of the immunization campaign in Orissa, India.
MedLine Citation:
PMID:  14870619     Owner:  NLM     Status:  MEDLINE    
A study was carried out in Orissa, India, to evaluate the impact on vitamin A status of vitamin A supplementation integrated with an immunization campaign. Data were collected from a representative sample of 1,811 children, aged 12 to 48 months, at baseline and then at 4 and 16 weeks following implementation of vitamin A supplementation. The primary outcome indicator was serum retinol. The coverage of vitamin A supplementation was 97%. There was a significant decline in the prevalence of Bitot's spots from 2.9% to 1.9% at 4 weeks, but the prevalence increased to 3.6% by 16 weeks. Serum retinol concentrations increased between baseline and 4 weeks (from 0.62 +/- 0.32 to 0.73 +/- 0.23 mumol/L, p < .001) but then decreased to 0.50 +/- 0.19 mumol/l at 16 weeks, which was significantly lower than at baseline (p < .001). The greatest increase in serum retinol from baseline to 4-week follow-up was among children with lowest baseline serum retinol and children with Bitot's spots at baseline. This study demonstrates the short-term benefits of vitamin A supplementation to be significant, especially for those whose status is most compromised. At the same time, the benefit of vitamin A supplementation in this population was transient. The impact of the vitamin A could not be sustained for the full 16 weeks in the study population. This finding calls for exploration of other means to improve vitamin A status, perhaps by adjusting the vitamin A supplementation schedule with more aggressive measures to improve intake of foods rich in bioavailable vitamin A, such as small amounts of animal foods or fortified foods. The study demonstrates the feasibility of integrating vitamin A supplementation with immunization campaigns.
Jonathan Gorstein; P Bhaskaram; Sultana Khanum; Reza Hossaini; N Balakrishna; Tracey S Goodman; Bruno deBenoist; Kamala Krishnaswamy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food and nutrition bulletin     Volume:  24     ISSN:  0379-5721     ISO Abbreviation:  Food Nutr Bull     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-02-11     Completed Date:  2004-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906418     Medline TA:  Food Nutr Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  319-31     Citation Subset:  IM    
Program for Appropriate Technology in Health (PATH), 1455 NW Leary Way, Seattle, WA 98107, USA.
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MeSH Terms
Child, Preschool
Dietary Supplements*
Drug Administration Schedule
Health Promotion
Immunization Programs
India / epidemiology
Nutritional Status
Poliomyelitis / prevention & control
Poliovirus Vaccine, Oral / administration & dosage*
Public Health
Time Factors
Treatment Outcome
Vitamin A / administration & dosage*,  blood*
Vitamin A Deficiency / epidemiology,  prevention & control*
Reg. No./Substance:
0/Poliovirus Vaccine, Oral; 11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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