Document Detail

Safety of human growth hormone therapy: current topics.
MedLine Citation:
PMID:  8627474     Owner:  NLM     Status:  MEDLINE    
Current data on patients treated with human growth hormone (GH) were analyzed for the following safety topics. New leukemia. Thirteen of 46 new cases of leukemia were in non-Japanese patients without risk factors for leukemia (compared with at least 13 new cases expected). A possible increased occurrence of leukemia with GH treatment appears to be limited to patients with risk factors. Nonleukemic extracranial neoplasms. The number of cases reported (10) does not differ significantly from the number expected. Acute pancreatitis. In five of the seven cases reported risk factors (renal failure, valproic acid use, insulin-dependent diabetes mellitus) were present. The available data do not indicate a clear cause-and-effect relation between GH therapy and pancreatitis. Prepubertal gynecomastia. Of 15 possible cases, two were pubertal, eight resolved or improved with continued GH therapy, and two resolved with the cessation of GH therapy. An effect of GH treatment on prepubertal gynecomastia remains unknown. Scoliosis. Scoliosis is reported in fewer than 1 percent of the patients in the National Cooperative Growth Study (general-population prevalence, 1.5% to 3%). Curvature progression can occur during growth acceleration, and a causal association with GH treatment is not substantiated. Pigmented nevi. Nevi growth may be increased with GH treatment. Biopsies have detected no neoplasia or premalignant nevi transformations.
D B Allen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  128     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-06-21     Completed Date:  1996-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S8-13     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Wisconsin Children's Hospital, Madison 53792, USA.
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MeSH Terms
Adverse Drug Reaction Reporting Systems / statistics & numerical data
Child, Preschool
Databases, Factual / statistics & numerical data
Growth Disorders / drug therapy,  epidemiology
Growth Hormone / adverse effects*,  therapeutic use
Gynecomastia / epidemiology
Nevus, Pigmented / epidemiology
Pancreatitis / epidemiology
Scoliosis / epidemiology
Turner Syndrome / epidemiology
Reg. No./Substance:
9002-72-6/Growth Hormone
Comment In:
J Pediatr. 2001 Mar;138(3):448-9   [PMID:  11241065 ]

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