Document Detail


Safety and feasibility of intra-arterial bivalirudin bolus administration during primary angioplasty.
MedLine Citation:
PMID:  23835668     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIM: We investigated the feasibility and safety of intra-arterial bivalirudin bolus during primary angioplasty.
BACKGROUND: Bivalirudin has been shown to be an effective and safe anticoagulant during angioplasty. However, in the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction trial, the bivalirudin group experienced higher acute stent thrombosis rate compared with the heparin and glycoprotein IIb/IIIa inhibitor group. One possible explanation is suboptimal systemic administration.
METHODS: To prevent this possibility and to potentially prevent acute stent thrombosis, we administered intra-arterial bivalirudin bolus during primary angioplasty in 100 consecutive patients.
RESULTS: Our observational study suggests safety with no bleeding episode and no observed acute stent thrombosis.
CONCLUSION: We conclude that intra-arterial bivalirudin bolus during primary angioplasty is safe and could ensure effective systemic delivery of bivalirudin.
Authors:
Amy Chorzempa; Jacqueline Tamis; Claude Simon; Angela Palazzo; Robert Leber; David Coven; Mun K Hong
Related Documents :
25082818 - Parent artery occlusion in large, giant, or fusiform aneurysms of the carotid siphon: c...
1864398 - Popliteal venous aneurysms with or without pulmonary embolism.
20546118 - Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinica...
23044478 - A systematic review of the outcomes of distal upper extremity bypass surgery with arter...
15906578 - Left atrial, pulmonary vein and dural calcification in a patient with arrhythmia and ch...
12848888 - Transesophageal echocardiographic identification of bilateral vertebral artery ostial s...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  24     ISSN:  1473-5830     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  419-21     Citation Subset:  IM    
Affiliation:
Cardiac Catheterization Laboratory, St. Luke's-Roosevelt Hospital Center, New York, New York, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cystatin C associates with the prediction of in-stent restenosis among patients receiving stent impl...
Next Document:  The Effect of Systemic Erythropoietin Treatment on Retinal Nerve Fiber Layer Parameters in Patients ...