Document Detail

Safety and feasibility of intra-arterial bivalirudin bolus administration during primary angioplasty.
MedLine Citation:
PMID:  23835668     Owner:  NLM     Status:  In-Data-Review    
AIM: We investigated the feasibility and safety of intra-arterial bivalirudin bolus during primary angioplasty.
BACKGROUND: Bivalirudin has been shown to be an effective and safe anticoagulant during angioplasty. However, in the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction trial, the bivalirudin group experienced higher acute stent thrombosis rate compared with the heparin and glycoprotein IIb/IIIa inhibitor group. One possible explanation is suboptimal systemic administration.
METHODS: To prevent this possibility and to potentially prevent acute stent thrombosis, we administered intra-arterial bivalirudin bolus during primary angioplasty in 100 consecutive patients.
RESULTS: Our observational study suggests safety with no bleeding episode and no observed acute stent thrombosis.
CONCLUSION: We conclude that intra-arterial bivalirudin bolus during primary angioplasty is safe and could ensure effective systemic delivery of bivalirudin.
Amy Chorzempa; Jacqueline Tamis; Claude Simon; Angela Palazzo; Robert Leber; David Coven; Mun K Hong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  24     ISSN:  1473-5830     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  419-21     Citation Subset:  IM    
Cardiac Catheterization Laboratory, St. Luke's-Roosevelt Hospital Center, New York, New York, USA.
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