| Safety and feasibility of autologous umbilical cord blood transfusion in 2 toddlers with cerebral palsy and the role of low dose granulocyte-colony stimulating factor injections. | |
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MedLine Citation:
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PMID: 21335665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Cerebral palsy (CP) with a prevalence of 2.1 per 1,000 live births generates variable degrees of incurable developmental disability. The aim of the present report was to provide insight in the safety and feasibility of autologous umbilical cord blood (UCB) transfusion with low dose Granulocyte Colony Stimulating Factor (G-CSF) injections in improving the functional outcome of children with cerebral palsy. METHODS: Two toddlers with diagnosed CP were given autologous umbilical cord blood (UCB) transfusion accompanied by low dose subcutaneous granulocyte colony stimulating factor (G-CSF) injections. RESULTS: Gross Motor Function Classification System (GMFCS) improvements were seen in both without any side effects being noted to date. CONCLUSION: In this first report, autologous UCB based intervention in tandem with low dose sc G-CSF administration seems to be feasible and safe with encouraging functional outcome improvements in children with CP. |
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Authors:
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Konstantinos I Papadopoulos; Sharon Su Shing Low; Tar Choon Aw; Teerachai Chantarojanasiri |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Restorative neurology and neuroscience Volume: 29 ISSN: 0922-6028 ISO Abbreviation: Restor. Neurol. Neurosci. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-21 Completed Date: 2012-01-17 Revised Date: 2012-04-05 |
Medline Journal Info:
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Nlm Unique ID: 9005499 Medline TA: Restor Neurol Neurosci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 17-22 Citation Subset: IM |
Affiliation:
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THAI StemLife, 23rd fl., The Offices at Central World, Patumwan, Bangkok, Thailand. kostas@thaistemlife.co.th |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Transfusion, Autologous
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adverse effects,
methods* Cerebral Palsy / drug therapy, physiopathology, therapy* Child, Preschool Combined Modality Therapy / adverse effects, methods Feasibility Studies Fetal Blood / transplantation* Granulocyte Colony-Stimulating Factor / administration & dosage*, adverse effects Humans Male |
| Chemical | |
Reg. No./Substance:
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143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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