Document Detail

Safety and feasibility of achieving lower systolic blood pressure goals in persons with type 2 diabetes: the SANDS trial.
MedLine Citation:
PMID:  19817934     Owner:  NLM     Status:  MEDLINE    
The Stop Atherosclerosis in Native Diabetics Study (SANDS) was a randomized open-label clinical trial in type 2 diabetics designed to examine the effects of intensive reduction of blood pressure, aggressive vs standard goals (< or =115/75 mm Hg vs < or =130/80 mm Hg), and low-density lipoprotein (LDL) cholesterol on the composite outcome of change in carotid intimal-medial thickness and cardiovascular events. The study demonstrated that in conjunction with a lower LDL cholesterol target of 70 mg/dL, aggressive systolic blood pressure-lowering resulted in a reduction in carotid intimal-medial thickness and left ventricular mass without measurable differences in cardiovascular events. The blood pressure treatment algorithm included renin-angiotensin system blockade, with other agents added if necessary. The authors conclude that both standard and more aggressive systolic blood pressure reduction can be achieved with excellent safety and good tolerability in patients with type 2 diabetes mellitus.
Matthew R Weir; Fawn Yeh; Angela Silverman; Richard B Devereux; James M Galloway; Jeffrey A Henderson; William J Howard; Marie Russell; Charlton Wilson; Robert Ratner; John Sorkin; Jason G Umans; Jerome L Fleg; Mario Stylianou; Elisa Lee; Barbara V Howard
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  11     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-12     Completed Date:  2010-01-06     Revised Date:  2014-10-03    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  540-8     Citation Subset:  IM    
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / adverse effects,  therapeutic use
Angiotensin-Converting Enzyme Inhibitors / adverse effects,  therapeutic use
Antihypertensive Agents / adverse effects,  therapeutic use*
Blood Pressure / physiology*
Cardiovascular Diseases / etiology,  prevention & control
Cholesterol, LDL / blood
Diabetes Mellitus, Type 2 / blood,  complications*,  physiopathology
Drug Tolerance
Hypertension / drug therapy*,  physiopathology*
Lisinopril / adverse effects,  therapeutic use
Losartan / adverse effects,  therapeutic use
Middle Aged
United States
Grant Support
1U01 HL67031-01A1/HL/NHLBI NIH HHS; U01 HL067031/HL/NHLBI NIH HHS; U01 HL067031-01A1/HL/NHLBI NIH HHS; U01 HL067031-02/HL/NHLBI NIH HHS; U01 HL067031-03/HL/NHLBI NIH HHS; U01 HL067031-04/HL/NHLBI NIH HHS; U01 HL067031-04S1/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Cholesterol, LDL; E7199S1YWR/Lisinopril; JMS50MPO89/Losartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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