Document Detail

Safety evaluation of protein of silkworm (Antheraea pernyi) pupae.
MedLine Citation:
PMID:  16510230     Owner:  NLM     Status:  MEDLINE    
The protein of silkworm pupae (PSP) has been thought to be a new available source of high quality protein that contains all the amino acids needed by the human body. The safety of PSP was evaluated systematically by a series of acute and sub-acute toxicological tests: (i) Acute toxicity test: The oral maximum tolerated dose of PSP was more than 15.0 g/kg body weight in mice, due to the absence of toxicity according to the criteria of acute toxic classifications; (ii) Mutagenicity test: PSP had no mutagenicity, as judged by a negative Ames test, mouse bone marrow cell micronucleus test and mouse sperm abnormality test; (iii) 30 days feeding study: No deaths or abnormal hematological, clinical chemical and histopathological changes and clinical signs had been found in rats when administrated PSP at 0.30, 0.75 and 1.50 g/kg/day to the rats for 30 days in each group during the test, respectively. No statistically significant differences had been found in body weights, food consumption and food efficiency of rats in each test group (P>0.05). These results indicate that PSP can be generally regarded as safe at a maximum dose of 1.50 g/kg/day in rats.
Jun Zhou; Dingxian Han
Publication Detail:
Type:  Journal Article     Date:  2006-02-28
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  44     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1123-30     Citation Subset:  IM    
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China.
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MeSH Terms
Blood Cell Count
Body Weight / drug effects
Eating / drug effects
Insect Proteins / toxicity*
Micronucleus Tests
Moths / chemistry*
Mutagenicity Tests
Pupa / chemistry*
Rats, Sprague-Dawley
Spermatozoa / chemistry,  drug effects
Weight Gain / drug effects
Reg. No./Substance:
0/Insect Proteins

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