| Safety and efficacy of tolterodine extended release in men with overactive bladder symptoms and presumed non-obstructive benign prostatic hyperplasia. | |
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MedLine Citation:
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PMID: 17906864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with presumed non-obstructive BPH (Q (max )>or= 15 ml/s) treated with tolterodine ER 4 mg/day for OAB symptoms, alone or added to unsuccessful alpha-blocker treatment of >or=6 weeks duration, were observed for 12 weeks in a non-interventional study to generate real-life efficacy and safety data. Patients completed the IPSS, the OAB-q and a 2-day micturition diary at baseline and 12 weeks. PVR was determined sonographically. Seven hundred and forty one patients were analysed. Mean PVR did not increase (25.4 +/- 26.5 vs. 29.3 +/- 30.9 ml at baseline). AUR requiring catheterization occurred in two patients, acute UTI in four patients. Median IPSS total scores decreased from 17 to 10, IPSS QoL scores from 4 to 2, OAB-q symptom bother scores from 50.0 to 22.5 and OAB-q HRQL scores increased from 59.2 to 81.6. In men with OAB symptoms and presumed non-obstructive BPH, tolterodine ER provided considerable symptomatic and QoL improvements with a low risk of AUR, acute UTI, or increased PVR. |
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Authors:
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K Höfner; M Burkart; G Jacob; U Jonas |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-29 |
Journal Detail:
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Title: World journal of urology Volume: 25 ISSN: 0724-4983 ISO Abbreviation: World J Urol Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-13 Completed Date: 2008-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8307716 Medline TA: World J Urol Country: Germany |
Other Details:
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Languages: eng Pagination: 627-33 Citation Subset: IM |
Affiliation:
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Urologische Klinik, Evangelisches Krankenhaus Oberhausen, Virchowstrasse 20, 46047 Oberhausen, Germany. klaus.hoefner@freenet.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Benzhydryl Compounds / administration & dosage*, adverse effects Cresols / administration & dosage*, adverse effects Delayed-Action Preparations Humans Male Middle Aged Muscarinic Antagonists / administration & dosage*, adverse effects Phenylpropanolamine / administration & dosage*, adverse effects Prostatic Hyperplasia / drug therapy*, psychology Quality of Life Regression Analysis Severity of Illness Index Treatment Outcome Urinary Bladder, Overactive / drug therapy*, psychology Urinary Incontinence, Urge / drug therapy, psychology Urodynamics |
| Chemical | |
Reg. No./Substance:
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0/Benzhydryl Compounds; 0/Cresols; 0/Delayed-Action Preparations; 0/Muscarinic Antagonists; 124937-51-5/tolterodine; 14838-15-4/Phenylpropanolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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