Document Detail


Safety and efficacy of preoperative portal vein embolization with polyvinyl alcohol in 58 patients with liver metastases.
MedLine Citation:
PMID:  16304024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of our study was to evaluate the safety and efficacy of transhepatic lobar portal vein embolization (PVE) using polyvinyl alcohol (PVA) particles to induce contralateral lobar hypertrophy in patients with liver-only metastases and normal underlying liver function. MATERIALS AND METHODS: Fifty-eight consecutive patients with small predicted future liver remnants (FLRs) underwent PVE with PVA particles to induce hypertrophy of the contralateral hemi-liver before surgical resection of liver metastases. Total liver, right hemi-liver, and left hemi-liver volumes were calculated before and after embolization using a 3D workstation. RESULTS: Eight patients underwent left PVE; 47, right PVE; and three, right and segment IV PVE. There were no major complications of the procedure. The mean increases in the ratio of the FLR to the total estimated liver volume after right, right and segment IV, and left PVE were 9%, 10%, and 3%, respectively; the corresponding mean hypertrophy ratios were 24.3%, 31.9%, and 1.5%, respectively. CONCLUSION: Right PVE using PVA particles alone as the embolic agent is safe and effective in achieving left hemi-liver hypertrophy. In contrast, left PVE did not induce significant right hemi-liver hypertrophy in this patient population.
Authors:
Anne M Covey; Scott Tuorto; Lynn A Brody; Constantinos T Sofocleous; Johanna Schubert; Hendrik von Tengg-Kobligk; George I Getrajdman; Lawrence H Schwartz; Yuman Fong; Karen T Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  185     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-01-27     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1620-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. coveya@mskcc.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Embolization, Therapeutic / methods*
Female
Humans
Imaging, Three-Dimensional
Liver Function Tests
Liver Neoplasms / radiography,  secondary,  therapy*
Male
Middle Aged
Phlebography
Polyvinyl Alcohol / therapeutic use*
Portal Vein*
Preoperative Care
Radiography, Interventional
Retrospective Studies
Tomography, X-Ray Computed
Treatment Outcome
Chemical
Reg. No./Substance:
9002-89-5/Polyvinyl Alcohol
Comments/Corrections
Comment In:
AJR Am J Roentgenol. 2006 Jul;187(1):W125; author reply 126   [PMID:  16794127 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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