| Safety and efficacy of isolated limb perfusion in elderly melanoma patients. | |
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MedLine Citation:
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PMID: 12464588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Older patients are assumed to have a higher risk of complications from isolated limb perfusion (ILP). A study was performed evaluating the safety and efficacy of ILP in patients older than 75 years with advanced melanoma of the limbs. METHODS: A total of 218 therapeutic ILPs with melphalan with or without tumor necrosis factor alpha were performed in 202 patients with advanced measurable melanoma and were analyzed retrospectively. Fifty-three patients (28%) were 75 years or older. RESULTS: Complete response rates were 56% for those older than 75 years and 58% for the younger group (P =.79). Locoregional relapse occurred in 56% of the older group versus 51% in the younger group (P =.61). Limb toxicity, systemic toxicity, local complications, and long-term morbidity were similar in both age groups. Perioperative mortality was low, with one procedure-related death in the older group. Older patients stayed in the hospital for a median of 23 days (younger patients, 19 days; P <.01). CONCLUSIONS: ILP results in similar response rates in the elderly with recurrent melanoma, without increased toxicity, complications, or long-term morbidity compared with younger patients. Older age in itself is not a contraindication for ILP. |
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Authors:
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E M Noorda; B C Vrouenraets; O E Nieweg; A N van Geel; A M M Eggermont; B B R Kroon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of surgical oncology Volume: 9 ISSN: 1068-9265 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-04 Completed Date: 2003-03-18 Revised Date: 2007-07-18 |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 968-74 Citation Subset: IM |
Affiliation:
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Department of Surgery, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. e.noorda@nki.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aged, 80 and over Antineoplastic Agents, Alkylating / administration & dosage, adverse effects Antineoplastic Combined Chemotherapy Protocols / therapeutic use Chemotherapy, Cancer, Regional Perfusion / adverse effects, methods* Disease-Free Survival Extremities* Female Humans Length of Stay Linear Models Male Melanoma / drug therapy*, mortality, pathology Melphalan / administration & dosage, adverse effects Multivariate Analysis Netherlands / epidemiology Retrospective Studies Skin Neoplasms / drug therapy*, mortality, pathology Survival Rate Tumor Necrosis Factor-alpha / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Alkylating; 0/Tumor Necrosis Factor-alpha; 148-82-3/Melphalan |
| Comments/Corrections | |
Comment In:
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Ann Surg Oncol. 2002 Dec;9(10):939-40
[PMID:
12464583
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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