Document Detail


Safety and efficacy of human growth hormone treatment in girls with Turner syndrome.
MedLine Citation:
PMID:  8359788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Six major adverse medical events (AMEs) and 44 minor AMEs were recorded in 6 and 23 patients, respectively, during human growth hormone (GH) treatment of Turner syndrome, equivalent to 118 treatment years. During the first year of GH treatment, there was no change in the SD score (SDS) for systolic or diastolic blood pressure. In a subgroup of 20 patients, there was no change in psychological tests, oral glucose tolerance, glycosylated haemoglobin or serum triglycerides over the first year of GH treatment. The mean total serum cholesterol level fell over this period. The low incidence of adverse medical problems during GH treatment complemented its efficacy. Height velocity in the first year was 7.7 +/- 1.8 cm/year (mean +/- SD) and was correlated with maternal height SDS, though not with paternal height SDS. Some 36% of first-year height velocity SDS could be predicted by the dose of GH and maternal height SDS.
Authors:
D A Price; P E Clayton; E H Crowne; C R Roberts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  39 Suppl 2     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1993  
Date Detail:
Created Date:  1993-09-30     Completed Date:  1993-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  44-8     Citation Subset:  IM    
Affiliation:
Department of Child Health, Manchester University, Royal Manchester Children's Hospital, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Behavior / drug effects
Blood Glucose / analysis
Blood Pressure / drug effects
Body Height / drug effects
Child
Dose-Response Relationship, Drug
Encopresis / chemically induced,  psychology
Enuresis / chemically induced,  psychology
Female
Growth / drug effects*
Growth Hormone / adverse effects*,  therapeutic use
Hemoglobin A, Glycosylated / analysis
Humans
Lymphedema / chemically induced
Recombinant Proteins / adverse effects,  therapeutic use
Regression Analysis
Seizures / chemically induced
Tic Disorders / chemically induced
Triglycerides / blood
Turner Syndrome / drug therapy*,  psychology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Recombinant Proteins; 0/Triglycerides; 9002-72-6/Growth Hormone

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