| Safety and efficacy of human growth hormone treatment in girls with Turner syndrome. | |
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MedLine Citation:
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PMID: 8359788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Six major adverse medical events (AMEs) and 44 minor AMEs were recorded in 6 and 23 patients, respectively, during human growth hormone (GH) treatment of Turner syndrome, equivalent to 118 treatment years. During the first year of GH treatment, there was no change in the SD score (SDS) for systolic or diastolic blood pressure. In a subgroup of 20 patients, there was no change in psychological tests, oral glucose tolerance, glycosylated haemoglobin or serum triglycerides over the first year of GH treatment. The mean total serum cholesterol level fell over this period. The low incidence of adverse medical problems during GH treatment complemented its efficacy. Height velocity in the first year was 7.7 +/- 1.8 cm/year (mean +/- SD) and was correlated with maternal height SDS, though not with paternal height SDS. Some 36% of first-year height velocity SDS could be predicted by the dose of GH and maternal height SDS. |
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Authors:
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D A Price; P E Clayton; E H Crowne; C R Roberts |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone research Volume: 39 Suppl 2 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 1993 |
Date Detail:
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Created Date: 1993-09-30 Completed Date: 1993-09-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 44-8 Citation Subset: IM |
Affiliation:
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Department of Child Health, Manchester University, Royal Manchester Children's Hospital, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Behavior / drug effects Blood Glucose / analysis Blood Pressure / drug effects Body Height / drug effects Child Dose-Response Relationship, Drug Encopresis / chemically induced, psychology Enuresis / chemically induced, psychology Female Growth / drug effects* Growth Hormone / adverse effects*, therapeutic use Hemoglobin A, Glycosylated / analysis Humans Lymphedema / chemically induced Recombinant Proteins / adverse effects, therapeutic use Regression Analysis Seizures / chemically induced Tic Disorders / chemically induced Triglycerides / blood Turner Syndrome / drug therapy*, psychology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Recombinant Proteins; 0/Triglycerides; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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