Document Detail

Safety and efficacy of clopidogrel treatment in Japanese patients undergoing drug-eluting stent implantation.
MedLine Citation:
PMID:  20122546     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Clopidogrel has been utilized as an antiplatelet therapy for patients undergoing stent implantation. In the Japanese population, however, the impact of clopidogrel on the occurrence of early adverse events is unknown. This study sought to evaluate procedural major bleeding and myocardial infarction in patients undergoing stent implantation with adjunctive clopidogrel compared with ticlopidine. METHODS AND RESULTS: The retrospective analysis included 311 patients who had stent implantation between January 2007 and April 2009. The patients were divided into groups with clopidogrel (n=159) and ticlopidine (n=152). Primary endpoint was major bleeding and myocardial infarction at 30 days. The incidence of major bleeding was 4.4% in the clopidogrel group vs. 3.9% in the ticlopidine group (p=0.94). The incidence of myocardial infarction was 3.8% in the clopidogrel group vs. 7.9% in the ticlopidine group (p=0.19). In patients with unstable angina, however, there was a strong trend toward lower incidence of myocardial infarction in patients treated with clopidogrel than those treated with ticlopidine (4.1% vs. 13.3%, p=0.08). The incidence of major bleeding was no different (1.4% vs. 5.3%, p=0.37). CONCLUSIONS: In patients with unstable angina and emergent coronary intervention, adjunctive clopidogrel therapy may have a slight positive impact on the prevention of myocardial infarction without increasing the risk of bleeding complications.
Fumiyuki Hayashi; Raisuke Iijima; Masato Nakamura; Kaoru Sugi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-09-19
Journal Detail:
Title:  Journal of cardiology     Volume:  55     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  34-40     Citation Subset:  IM    
Copyright Information:
2009 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Division of Cardiovascular Medicine, Ohashi Medical Center, Toho University, 2-17-6 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
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MeSH Terms
Drug-Eluting Stents*
Hemorrhage / prevention & control*
Myocardial Infarction / prevention & control*
Platelet Aggregation Inhibitors / therapeutic use*
Retrospective Studies
Ticlopidine / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel

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