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Safety and efficacy of the Aperio thrombectomy device when compared to the Solitaire AB/FR and the Revive devices in a pulsatile flow system.
MedLine Citation:
PMID:  23173104     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: There are a limited number of studies comparing the Aperio mechanical thrombectomy device to other stent-based devices. In this paper, we compared the Aperio thrombectomy device to the Solitaire AB, FR and Revive devices in a model of the middle cerebral artery (MCA) within a modified pulsatile flow system.
METHODS: Thrombi made of lamb's blood were placed into a pulsatile flow system perfused with Hartmann's solution at 80 bpm with a mean pressure of 90 mm Hg. 30 experiments were run with each device.
RESULTS: Recanalization rates were similar for all three devices (90% with the Solitaire AB, FR, 80% with the Revive, and 90% with the Aperio). The mean number of attempts to retrieve the thrombus was also similar for all three devices (1.7 with the Solitaire AB, FR, 2.1 with the Revive, 1.6 with the Aperio). Clot fragmentation and embolization rates revealed no statistical significance but there was a trend towards lower embolization rates with the Aperio (23% compared to 40% with the Solitaire AB, FR and 47% with the Revive). The Aperio was the fastest to recanalize the MCA (mean of 66 seconds compared to 186 seconds for the Solitaire AB, FR and 169 seconds for the Revive).
CONCLUSIONS: In this in vitro setting, the Aperio device seems to be an efficacious and safe device when compared to other similar clinically used mechanical thrombectomy devices. Larger clinical trials are warranted.
Authors:
Mahdi Saleh; John Nathan Spence; Sanjeev Nayak; Gillian Pearce; Christopher Tennuci; Christine Roffe
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Publication Detail:
Type:  Journal Article     Date:  2012-10-25
Journal Detail:
Title:  American journal of cardiovascular disease     Volume:  2     ISSN:  2160-200X     ISO Abbreviation:  Am J Cardiovasc Dis     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-22     Completed Date:  2012-11-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101569582     Medline TA:  Am J Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-8     Citation Subset:  -    
Affiliation:
Institute for Science and Technology in Medicine, Keele University Stoke-on-Trent, United Kingdom.
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