| Safety and effectiveness of infliximab for inflammatory bowel diseases in clinical practice. | |
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MedLine Citation:
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PMID: 20184089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Our aim was to assess the efficacy and safety of infliximab (IFX) in clinical practice in three Primary Care, Hospital Centers. MATERIAL AND METHODS: From September 2004 to December 2008 62 patients (28 males, 34 females, mean age 30.25 years, range 15-55 years), affected by ulcerative colitis (UC) (23 pts) or by Crohn's disease (CD) (39 patients) were treated. Clinical efficacy, safety, mucosal healing and quality of life were assessed both in UC and CD. RESULTS: A total of 746 infusions were performed. IFX was administered for a mean of 26 months (range 8-44 months). 33/39 (84.61%) pts with CD were in remission under treatment with IFX for a mean time of 19 months (range 12-44 months). Mean Crohn Disease Activity Index (CDAI) score decreased from 295 (range 258-346) to 136 (range 98-136) (p < 0.005). Inflammatory Bowel Disease Quality of Life (IBDQL) improved from 48 (at entry) to 198 (at the end of the study) (p < 0.005). 20/23 (86.95%) patients with UC were in remission under treatment with IFX for a mean of 18 months (range 8-34 months). Mean Disease Activity Index (DAI) decreased from 11 (range 9-12) to < 3 (range 2-3) (p < 0.05). Mean Mayo Subscore for Endoscopy decreased from 3 to < 1 (range 0-1). IBDQL improved from 56 (at entry) to 194 (at the end of the study) (p < 0.005). Only 5 patients (8.06%) experienced side-effects. CONCLUSIONS: Long-term outpatients treatment with IFX seems to be safe and effective in managing patients affected by IBD in clinical practice. |
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Authors:
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A Tursi; W Elisei; G Brandimarte; G Giorgetti; A Penna; V Castrignano |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: European review for medical and pharmacological sciences Volume: 14 ISSN: 1128-3602 ISO Abbreviation: Eur Rev Med Pharmacol Sci Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9717360 Medline TA: Eur Rev Med Pharmacol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 47-55 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, "Michele Sarcone" Hospital, Terlizzi, Bari, Italy. antotursi@tiscali.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Ambulatory Care Anti-Inflammatory Agents / adverse effects, therapeutic use* Antibodies, Monoclonal / adverse effects, therapeutic use* Colitis, Ulcerative / drug therapy, pathology Crohn Disease / drug therapy, pathology Female Gastrointestinal Agents / adverse effects, therapeutic use* Humans Inflammatory Bowel Diseases / drug therapy* Male Middle Aged Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/Gastrointestinal Agents; 0/infliximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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