Document Detail

Safety and effectiveness of an aggressive and individualized bath-PUVA regimen in the treatment of psoriasis.
MedLine Citation:
PMID:  7949478     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The optimal therapeutic regimen of bath-PUVA therapy of psoriasis is still under debate. OBJECTIVE: We investigated the safety and efficacy of an aggressive and individualized bath-PUVA regimen. METHODS: Two closely matched groups of 22 psoriatic patients were treated either with 30-min baths in 0.0003% 8-methoxypsoralen (8-MOP) aqueous solution or oral administration of the drug. According to the standard European regimen, treatments were delivered 4 times a week starting with the minimal phototoxic dose. RESULTS: Complete clearing or marked improvement was observed in all the patients. However, with bath-PUVA, the same therapeutic effect required smaller cumulative UVA doses (39.3 +/- 15.8 vs. 123.8 +/- 39.9 J/cm2) and lower numbers of exposures (15.2 +/- 4.4 vs. 20.6 +/- 4.2). Both differences were significant at the 0.01 level (Student's t test). Gastro-intestinal side-effects were of course restricted to oral 8-MOP. The incidences of burns and pruritus were similar. CONCLUSION: Using an aggressive and individualized schedule, bath-PUVA therapy showed a greater efficacy than oral PUVA therapy while being just as safe.
P G Calzavara-Pinton; B Ortel; H Hönigsmann; C Zane; G De Panfilis
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  189     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-02     Completed Date:  1994-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  256-9     Citation Subset:  IM    
Department of Dermatology Brescia University Hospital, Italy.
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MeSH Terms
Administration, Oral
Methoxsalen / administration & dosage
Middle Aged
PUVA Therapy* / methods
Psoriasis / drug therapy*
Reg. No./Substance:

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