| Safety and effectiveness of an aggressive and individualized bath-PUVA regimen in the treatment of psoriasis. | |
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MedLine Citation:
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PMID: 7949478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The optimal therapeutic regimen of bath-PUVA therapy of psoriasis is still under debate. OBJECTIVE: We investigated the safety and efficacy of an aggressive and individualized bath-PUVA regimen. METHODS: Two closely matched groups of 22 psoriatic patients were treated either with 30-min baths in 0.0003% 8-methoxypsoralen (8-MOP) aqueous solution or oral administration of the drug. According to the standard European regimen, treatments were delivered 4 times a week starting with the minimal phototoxic dose. RESULTS: Complete clearing or marked improvement was observed in all the patients. However, with bath-PUVA, the same therapeutic effect required smaller cumulative UVA doses (39.3 +/- 15.8 vs. 123.8 +/- 39.9 J/cm2) and lower numbers of exposures (15.2 +/- 4.4 vs. 20.6 +/- 4.2). Both differences were significant at the 0.01 level (Student's t test). Gastro-intestinal side-effects were of course restricted to oral 8-MOP. The incidences of burns and pruritus were similar. CONCLUSION: Using an aggressive and individualized schedule, bath-PUVA therapy showed a greater efficacy than oral PUVA therapy while being just as safe. |
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Authors:
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P G Calzavara-Pinton; B Ortel; H Hönigsmann; C Zane; G De Panfilis |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Dermatology (Basel, Switzerland) Volume: 189 ISSN: 1018-8665 ISO Abbreviation: Dermatology (Basel) Publication Date: 1994 |
Date Detail:
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Created Date: 1994-12-02 Completed Date: 1994-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203244 Medline TA: Dermatology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 256-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology Brescia University Hospital, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Baths* Female Humans Male Methoxsalen / administration & dosage Middle Aged PUVA Therapy* / methods Psoriasis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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298-81-7/Methoxsalen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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