Document Detail

Safety of drug eluting stents in patients on chronic anticoagulation using long-term single antiplatelet treatment with clopidogrel.
MedLine Citation:
PMID:  20146326     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Use of triple therapy with aspirin, clopidogrel, and anticoagulants significantly increases bleeding, thus drug eluting stents (DES) are usually avoided in patients requiring anticoagulation. We tested use of DES vs. BMS using a long-term therapy with clopidogrel only and anticoagulants in this group of patients. METHODS: We enrolled 165 consecutive patients, 79 receiving DES (age 67 +/- 9 years, 84% with atrial fibrillation) and 86 receiving bare metal stents (BMS) (age 70 +/- 11 years, 71% with atrial fibrillation). All patients received aspirin + clopidogrel + oral anticoagulants for 4 weeks, then aspirin was stopped and clopidogrel was continued during the 12-month follow-up. Primary end point was the combined incidence of major adverse coronary events and major bleedings. RESULTS: Incidence of the primary endpoint was 10.1% in patients with DES and 26.7% in patients with BMS (P = 0.01). There was a large difference in incidence of target vessel revascularization (8.1% for DES, 23.3% for BMS, P = 0.01), whereas incidence of myocardial infarction (3.8% in DES vs. 8.1% in BMS) and major bleeding (1.3% vs. 2.3%, respectively) were not significantly different. There were no cases of stent thrombosis. On multivariate Cox regression analysis, the only factor associated with a reduced risk of the primary endpoint was use of DES (hazard ratio 0.35 with 95% confidence interval 0.14-0.85, P = 0.02). CONCLUSIONS: Results of our cohort study suggest that use of DES associated with a treatment with clopidogrel only may be safe and significantly reduce the need for new revascularization in patients requiring chronic anticoagulation.
Vincenzo Pasceri; Giuseppe Patti; Christian Pristipino; Francesco Pelliccia; Diego Irini; Antonio Varveri; Adriana Roncella; Germano Di Sciascio; Giulio Speciale
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  75     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  936-42     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Wiley-Liss, Inc.
Interventional Cardiology Unit, San Filippo Neri Hospital, Rome, Italy.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Anticoagulants / administration & dosage*
Aspirin / administration & dosage
Atrial Fibrillation / drug therapy
Coronary Artery Disease / epidemiology,  therapy*
Drug Therapy, Combination
Drug-Eluting Stents*
Middle Aged
Multivariate Analysis
Platelet Aggregation Inhibitors / administration & dosage*
Ticlopidine / administration & dosage,  analogs & derivatives*
Reg. No./Substance:
0/Anticoagulants; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel
Comment In:
Catheter Cardiovasc Interv. 2010 May 1;75(6):943-5   [PMID:  20432400 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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