Document Detail


Safety of coronary stenting early after thrombolysis in patients with acute myocardial infarction: one- and six-month clinical and angiographic evolution.
MedLine Citation:
PMID:  11948893     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the feasibility and safety of early posthrombolysis coronary stenting and the incidence of further reocclusion, we followed 99 consecutive patients with acute myocardial infarction thrombolyzed with rt-PA 2.0 +/- 0.8 hr after onset. Culprit artery was stented 14.0 +/- 7.0 hr after thrombolysis. All patients underwent clinical and angiographic follow-up at 1 and 6 months. Angiographic success was achieved in 99% of cases. Neither major cardiac events nor bleeding or vascular complications occurred during hospital stay. At 30 days, no events occurred and normal flow persisted in all stented arteries. At 6 months, only one artery reoccluded (1%), resulting in a nonfatal reinfarction. Restenosis rate was 21%. Contribution of the infarcted area to left ventricular function significantly increased from baseline to 30-day and to 6-month evaluations. Thus, early posthrombolysis stenting is a safe strategy with a low reocclusion rate, which seems to allow functional recovery of the infarcted area. Further studies are necessary to define its impact on survival and cost-effectiveness.
Authors:
Francisco Fernández-Avilés; Joaquín J Alonso; Federico Gimeno; Benigno Ramos; Juan M Durán; José Bermejo; Luis de La Fuente; Juan C Muñoz; Isabel Garcimartín; Emilio García-Morán; Olga Sanz; Ana Serrador; José A San Román
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  55     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  467-76     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Affiliation:
Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico-Universitario, Valladolid, Spain. faviles@secardiologia.es
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Vessel Prosthesis Implantation / adverse effects*
Cohort Studies
Coronary Angiography*
Feasibility Studies
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction / drug therapy*,  radiography,  surgery*
Plasminogen Activators / therapeutic use*
Prospective Studies
Stents / adverse effects*
Thrombolytic Therapy*
Time Factors
Tissue Plasminogen Activator / therapeutic use*
Chemical
Reg. No./Substance:
EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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