Document Detail

Safety of contrast flash-replenishment stress echocardiography in 500 patients with a chest pain episode of undetermined origin within the last 5 days.
MedLine Citation:
PMID:  19502619     Owner:  NLM     Status:  MEDLINE    
AIMS: Safety concerns regarding the use of echo-contrast agents during baseline and SE in patients with recent chest pain have been raised. The purpose of the present study was to provide evidence regarding the safety of flash-replenishment contrast dipyridamole-atropine echocardiography (DASE) in such patients. METHODS AND RESULTS: Five hundred consecutive individuals who presented to the Emergency Department with chest pain, normal electrocardiograms (ECG) and troponin I were selected based on a less than 5 days interval between chest pain episode and performance of contrast flash-replenishment DASE. Analysis of myocardial perfusion with SonoVue infusion after dipyridamole was routinely added on top of standard wall motion assessment during DASE. Adverse events (AEs) were reported according to standardized terminology and then compared with a historical control group in which contrast was not used. No deaths, myocardial infarctions, sustained arrhythmias, or any other life-threatening events were observed. Adverse events were not significantly different between the study group and the control group. In the selected subgroup of patients (n = 149) who underwent coronary angiography, accuracy of DASE with additional perfusion assessment was higher (88%, 95% C.I. 83-93%) than without (72%, 95% C.I. 65-79%). CONCLUSION: DASE with SonoVue infusion for myocardial perfusion assessment was exceptionally safe even when routinely performed within the first 5 days following a chest pain episode of undetermined origin in subjects without ECG and troponin abnormalities.
Nicola Gaibazzi; Angelo Squeri; Diego Ardissino; Claudio Reverberi
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Publication Detail:
Type:  Journal Article     Date:  2009-06-06
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  10     ISSN:  1532-2114     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-12     Completed Date:  2009-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  726-32     Citation Subset:  IM    
Heart Centre, Parma University Hospital, Parma, Italy.
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MeSH Terms
Chest Pain / ultrasonography*
Chi-Square Distribution
Contrast Media / administration & dosage,  adverse effects*
Coronary Angiography
Echocardiography, Stress / methods*
Infusions, Intravenous
Phospholipids / administration & dosage,  adverse effects*
Sensitivity and Specificity
Sulfur Hexafluoride / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Contrast Media; 0/Phospholipids; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride
Comment In:
Eur J Echocardiogr. 2009 Aug;10(6):713-5   [PMID:  19671627 ]

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